(2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyacetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyacetic acid
• 化学式: C₁₀H₆F₆O₃
• 分子量: 288.14
• InChiKey: ZVACZNUZAKRYHT-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-ALKOXY-1-(TRIFLUOROMETHYL-SUBSTITUTED PHENYL)ETHANOL DERIVATIVES<br/>[FR] PROCEDE DE PRODUCTION DE DERIVES 2-ALKOXY-1-(PHENYLE A SUBSTITUTION TRIFLUOROMETHYLE)ETHANOL OPTIQUEMENT ACTIFS
  申请人：CENTRAL GLASS CO LTD

  公开号：WO2004037760A2

  公开（公告）日：2004-05-06

  A process for producing an optically active 2-alkoxy-1-(trifluoromethyl-substituted phenyl)ethanol derivative represented by the formula 5: where R2 represents a C1-C6 lower alkyl group, n represents 1 or 2 and * represents a chiral carbon, includes the steps of (a) reducing an optically active, hydroxyl-protective, trifluoromethyl-substituted mandelate represented by the formula 1, by a hydride reducing agent, into an optically active, hydroxyl-protective 2-hydroxy-1-(trifluoromethyl-substituted phenyl)ethanol represented by the formula 2; (b) reacting the hydroxyl-protective hydroxyethanol represented by the formula 2, with an alkylation agent represented by the formula 3, in the presence of a base, thereby producing an optically active, hydroxyl-protective 2-alkoxy-1-(trifluoromethyl-substituted phenyl)ethanol represented by the formula 4; and (c) deprotecting the hydroxyl-protective alkoxyethanol represented by the formula 4 into the alkoxyethanol derivative represented by the formula 5.