(2-Nitrophenyl)sulfonylazanide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Nitrophenyl)sulfonylazanide
• 化学式: C6H5N2O4S-
• 分子量: 201.18
• InChiKey: RJJKQWLYRBGPJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Process for preparation of 2-aminotetralin derivatives and intermediates thereof
  申请人：Honda Tatsuya

  公开号：US20050153408A1

  公开（公告）日：2005-07-14

  The present invention is to efficiently and simply prepare an optically active 7-substituted-2-aminotetralin with industrial advantage. In the process, a 7-substituted-2-tetralone or its bisulfite adduct is reduced with a microorganism to an optically active 7-substituted-2-tetralol. Then, a sulfonyl group is introduced to the hydroxy group to form an optically active 7-substituted-2-sulfonyloxytetralin. Then, with inversion of the configuration, a nitrogen substituent is introduced using a nitrogen nucleophile to form an optically active 2,7-substituted tetralin. Furthermore, if necessary, the nitrogen substituent is converted into a non-substituted amino group. Thus, an optically active 7-substituted-2-aminotetralin or its salt is prepared.

  本发明旨在以工业优势高效简便地制备光学活性的7-取代-2-氨基四氢萘。在该过程中，使用微生物将7-取代-2-四氢萘酮或其亚硫酸盐加合物还原为光学活性的7-取代-2-四氢萘醇。然后，引入磺酰基到羟基上，以形成光学活性的7-取代-2-磺酰氧基四氢萘。接着，通过构型反演，使用氮亲核试剂引入氮取代基，以形成光学活性的2,7-取代四氢萘。此外，如有必要，氮取代基可转化为非取代的氨基。因此，制备了光学活性的7-取代-2-氨基四氢萘或其盐。
• PROCESS FOR PREPARATION OF 2-AMINOTETRALIN DERIVATIVES AND INTERMEDIATES THEREOF
  申请人：KANEKA CORPORATION

  公开号：EP1457570A1

  公开（公告）日：2004-09-15

  The present invention is to efficiently and simply prepare an optically active 7-substituted-2-aminotetralin with industrial advantage. In the process, a 7-substituted-2-tetralone or its bisulfite adduct is reduced with a microorganism to an optically active 7-substituted-2-tetralol. Then, a sulfonyl group is introduced to the hydroxy group to form an optically active 7-substituted-2-sulfonyloxytetralin. Then, with inversion of the configuration, a nitrogen substituent is introduced using a nitrogen nucleophile to form an optically active 2,7-substituted tetralin. Furthermore, if necessary, the nitrogen substituent is converted into a non-substituted amino group. Thus, an optically active 7-substituted-2-aminotetralin or its salt is prepared.

  本发明旨在高效、简单地制备具有工业优势的光学活性 7-取代-2-氨基四氢萘。 在制备过程中，用微生物将 7-取代-2-四氢萘酮或其亚硫酸氢盐加合物还原成具有光学活性的 7-取代-2-四氢萘酚。然后，在羟基上引入磺酰基，形成具有光学活性的 7-取代-2-磺酰氧基四氢萘。然后，在反转构型的情况下，使用氮亲核剂引入一个氮取代基，形成具有光学活性的 2,7-取代四氢萘。此外，如有必要，还可将氮取代基转化为非取代氨基。这样，一种具有光学活性的 7-取代-2-氨基四氢萘或其盐就制备出来了。
• METHOD AND DEVICE FOR DETECTING NUCLEIC ACID, AND KIT
  申请人：Kaneka Corporation

  公开号：EP2620508A1

  公开（公告）日：2013-07-31

  The present invention provides a method for detecting a nucleic acid, by which a multi-stranded nucleic acid amplified by a nucleic acid amplification method is detected easily and with a high degree of accuracy without the need for specialized equipment, and also provides a nucleic acid detection device. Provided are a method for detecting a nucleic acid under visible light via a color reaction produced by contact between a chromogenic leuco dye and the multi-stranded nucleic acid, as well as a nucleic acid detection device using this method.

  本发明提供了一种核酸检测方法，通过该方法，无需专门设备即可轻松、高精度地检测通过核酸扩增方法扩增的多链核酸，同时还提供了一种核酸检测装置。本发明提供了一种在可见光下通过发色性白兰地染料与多链核酸接触产生的颜色反应来检测核酸的方法，以及使用该方法的核酸检测装置。
• TYROSINE DERIVATIVES AS PPAR-GAMMA-MODULATORS
  申请人：Laboratorios SALVAT, S.A.

  公开号：EP1778624A1

  公开（公告）日：2007-05-02
• NUCLEIC ACID DETECTION METHOD, AND DEVICE AND KIT FOR USE IN SAME
  申请人：Kaneka Corporation

  公开号：EP2682480B1

  公开（公告）日：2017-05-03