N-(formamidomethyl)-benzamide | 1123761-49-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(formamidomethyl)-benzamide
• 英文别名: N-(formamidomethyl)benzamide
• CAS: 1123761-49-8
• 化学式: C₉H₁₀N₂O₂
• 分子量: 178.191
• InChiKey: VWTSSOFJQMONLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  马尿酸 、 formamide 在 ammonium peroxydisulfate 、 silver nitrate 作用下， 反应 0.5h， 以70%的产率得到N-(formamidomethyl)-benzamide
  参考文献：
  名称：

  Novel Route toN-Acyl-N′-formyl Aminal

  摘要：

  Oxidative decarboxylation of N-acyl amino acids induced by Ag+/S2O82 in formamide afforded N-acyl-N'-formyl aminal in 52-74% yields.

  DOI：

  10.1080/00397910802398256

文献信息

• Novel isoindole derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US20040053923A1

  公开（公告）日：2004-03-18

  This invention relates to compounds represented by the general formula [I] 1 wherein, R represents an azido group, etc., R 1 and R 2 are the same or different and represent hydrogen atoms, etc., R 3 and R 4 are the same or different and represent hydrogen atoms, etc., X 1 represents an oxygen atom, etc., X 2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

  本发明涉及由一般式[I]1表示的化合物，其中，R代表叠氮基等，R1和R2相同或不同，代表氢原子等，R3和R4相同或不同，代表氢原子等，X1代表氧原子等，X2代表氧原子等，Y代表氧原子等，Z代表紧缩芳基基团等，或其药学上可接受的盐，其制备方法以及作为治疗糖尿病的药物、预防糖尿病慢性并发症的预防剂或抗肥胖药物的有效成分，包含该化合物或其药学上可接受的盐。
• NOVEL ISOINDOLE DERIVATIVES
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1207161A1

  公开（公告）日：2002-05-22

  This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.

  本发明涉及通式[I]所代表的化合物 其中，R代表叠氮基等，R1和R2相同或不同且代表氢原子等，R3和R4相同或不同且代表氢原子等，X1代表氧原子等，X2代表氧原子等，Y代表氧原子等，Z代表缩合芳基等、或其药学上可接受的盐、其制备工艺，以及含有该化合物或其药学上可接受的盐作为有效成分的治疗糖尿病的药物、治疗糖尿病慢性并发症的预防药物或防治肥胖症的药物。
• Novel Route to<i>N</i>-Acyl-<i>N</i>′-formyl Aminal
  作者：Hong Yue、Hongmei Zhang、Meiling Wang、Wenhua Huang

  DOI：10.1080/00397910802398256

  日期：2009.1.13

  Oxidative decarboxylation of N-acyl amino acids induced by Ag+/S2O82 in formamide afforded N-acyl-N'-formyl aminal in 52-74% yields.
• US6608098B1
  申请人：——

  公开号：US6608098B1

  公开（公告）日：2003-08-19
• US6777410B2
  申请人：——

  公开号：US6777410B2

  公开（公告）日：2004-08-17