西尼二胺盐酸盐 | 958-93-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 西尼二胺盐酸盐
• 中文别名: 盐酸西尼二胺
• 英文名称: N,N-dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-ethylenediamine; hydrochloride
• 英文别名: N,N-Dimethyl-N'-[2]pyridyl-N'-[3]thienylmethyl-aethylendiamin; Hydrochlorid；Thenyldiamine hydrochloride；N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-3-ylmethyl)ethane-1,2-diamine;hydrochloride
• CAS: 958-93-0
• 化学式: C₁₄H₁₉N₃S*ClH
• 分子量: 297.852
• InChiKey: OQWLDKFPOJCKBX-UHFFFAOYSA-N

物化性质

• 熔点：
  169.5-170 °C
• 物理描述：
  Thenyldiamine hydrochloride is a white powder with a bitter taste. Melting point 169.5-170°C. Used as an antihistamine.
• 溶解度：
  greater than or equal to 100 mg/mL at 68° F (NTP, 1992)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Sesquiterpene lactones, extracts containing them, their preparation and pharmaceutical use
  申请人：R.P. SCHERER CORPORATION

  公开号：EP0098041A2

  公开（公告）日：1984-01-11

  A preparation for pharmaceutical use, especially in the treatment of migraine, arthritis and bronchial complaints contains a sesquiterpene lactone and may be an extract recovered from the plant Tanacetum parthenium by extraction using a non-polar solvent. Alternatively the preparation may be a sesquiterpene lactone per se or formulation containing it.

  一种药物制剂，尤其是用于治疗偏头痛、关节炎和支气管疾病的制剂，含有倍半萜内酯，可以是从植物丹参（Tanacetum parthenium）中通过使用非极性溶剂萃取得到的提取物。 或者，该制剂本身就是倍半萜内酯或含有倍半萜内酯的制剂。
• Process for production of vinyl chloride polymer
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0172427A2

  公开（公告）日：1986-02-26

  This process is a process for production of a vinyl chloride polymer by suspension polymerization or emulsion polymerization of vinyl chloride monomer or a mixture of vinyl chloride monomer with a vinyl monomer copolymerizable with said vinyl chloride monomer in an aqueous medium, characterized in that the polymerization is carried out in a polymerizer, the inner wall surface and portions of the auxiliary equipment thereof which may come into contact with the monomer during polymerization being previously coated with a scaling preventive comprising at least one selected from dyes, pigments and aromatic or heterocyclic compounds having at least 5 conjugated π bonds, while controlling the chloride ion concentration in the reaction mixture to not higher than 100 ppm. According to said process, scaling onto the inner wall surface of a polymerizer, etc. during polymerization can be prevented effectively and surely.

  该工艺是通过氯乙烯单体或氯乙烯单体与可与所述氯乙烯单体共聚的乙烯基单体混合物在水介质中进行悬浮聚合或乳液聚合来生产氯乙烯聚合物的工艺，其特征在于聚合是在聚合器中进行的、内壁表面及其辅助设备中可能在聚合过程中与单体接触的部分事先涂上一层防垢剂，该防垢剂至少包括一种选自染料、颜料和至少有 5 个共轭 π 键的芳香族或杂环化合物的防垢剂，同时控制反应混合物中的氯离子浓度不高于 100 ppm。根据上述工艺，可有效、可靠地防止聚合过程中聚合器等内壁表面结垢。
• Compositions and methods for combination ingredient delivery
  申请人：The FIX, LLC

  公开号：US10149822B2

  公开（公告）日：2018-12-11

  Described herein are compositions, methods, and devices for relief of a cough, cold, sore throat, or allergy, or a related symptom. Also described herein are compositions, methods, and devices for the prevention, treatment and/or amelioration of a digestive illness or digestive discomfort, or a related symptom of either. Such compositions may be in the form of a liquid composition and include a plurality of pharmaceutical ingredients and a plurality of botanical ingredients.

  本文描述的是用于缓解咳嗽、感冒、喉咙痛或过敏或相关症状的组合物、方法和装置。本文还描述了用于预防、治疗和/或改善消化系统疾病或消化系统不适或两者相关症状的组合物、方法和装置。此类组合物可以是液体组合物的形式，包括多种药物成分和多种植物成分。
• Alternating sympathomimetic therapy for the treatment of respiratory ailments
  申请人：Sovereign Pharmaceuticals, LLC

  公开号：US10098856B2

  公开（公告）日：2018-10-16

  A combination of dosage units for alleviating respiratory ailments and a method of alleviating respiratory ailments which uses this combination of dosage units. The dosage units comprise one or more first dosage units comprising pseudoephedrine and/or a pharmaceutically acceptable salt thereof and one or more second dosage units comprising phenylephrine and/or a pharmaceutically acceptable salt thereof.

  一种用于缓解呼吸系统疾病的组合剂量单位和一种使用这种组合剂量单位的缓解呼吸系统疾病的方法。这些剂量单位包括一个或多个由伪麻黄碱和/或其药学上可接受的盐组成的第一剂量单位和一个或多个由苯肾上腺素和/或其药学上可接受的盐组成的第二剂量单位。
• Composition and method for treatment of symptoms associated with various skin conditions
  申请人：THERACEUTIX, LLC

  公开号：US10624877B2

  公开（公告）日：2020-04-21

  Compositions containing imidazole-based compounds, and optionally, colloidal oatmeal, for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin. Also, methods for the treatment, prevention, and management of symptoms, conditions, diseases, and disorders of the skin using compositions containing imidazole-based compounds, and optionally, colloidal oatmeal.

  用于治疗、预防和控制皮肤症状、状况、疾病和失调的含有咪唑类化合物和可选胶体燕麦片的组合物。此外，使用含有咪唑类化合物的组合物和可选的胶体燕麦片治疗、预防和控制皮肤症状、状况、疾病和失调的方法。