2-(1-Adamantyl)-4-methylestrone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-(1-Adamantyl)-4-methylestrone
• 英文别名: 2-(1-admantanyl)-3-hydroxy-4-methylestra-1,3,5(10)-trien-17-one；3-hydroxy-2-adamantyl(1)-4-methylestra-1,3,5(10)-trien-17-one；ZYC26；2-(1-adamantyl)-3-hydroxy-4-methylestra-1,3,5(10)-trien-17-one；(8R,9S,13S,14S)-2-(1-adamantyl)-3-hydroxy-4,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
• 化学式: C₂₉H₃₈O₂
• 分子量: 418.62
• InChiKey: ACIKKZKZKINENW-DGGJTPRQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-金刚烷醇 、 3-hydroxy-4-methylestra-1,3,5(10)-trien-17-one 在 三氟化硼乙醚 作用下， 以 正戊烷 为溶剂， 反应 1.0h， 以68%的产率得到2-(1-Adamantyl)-4-methylestrone
  参考文献：
  名称：

  Modified, hydroxy-substituted aromatic structures having cytoprotective activity

  摘要：

  本发明涉及一种为细胞群体提供细胞保护作用的过程，包括向该细胞群体施用一种包含一个氢氧基取代芳环结构和一个与之相连的非融合多环疏水取代基的化合物。具体来说，本发明涉及一种这样的过程，其中所施用的化合物是酚类的，例如类固醇（例如雌激素），并且具有一个与其氢氧基取代A环相连接的非融合多环疏水取代基。

  公开号：

  US09156876B2

文献信息

• MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY
  申请人：Covey F. Douglas

  公开号：US20060009438A2

  公开（公告）日：2006-01-12

  Abstract of the Disclosure The present invention is directed to a process for conferring cytoprotection on a population of cells which comprises administering to that population of cells a compound comprising a hydroxy-substituted aromatic ring structure and a non-fused polycyclic, hydrophobic substituent attached thereto. In particular, the present invention is directed to such a process wherein the administered compound is phenolic, such as a steriod (e.g., estrogen), and has a non-fused polycyclic, hydrophobic substituent attached to the hydroxy-substituted A-ring thereof.

  本发明涉及一种用于给细胞群体提供细胞保护的方法，该方法包括向该细胞群体中投与一种化合物，所述化合物包含一个羟基取代的芳香环结构和一个附着于其上的非融合多环、疏水取代基。特别地，本发明涉及一种这样的方法，其中所投与的化合物为酚类，例如类固醇（例如雌激素），并且具有附着于其羟基取代的A环上的非融合多环、疏水取代基。
• US6844456B2
  申请人：——

  公开号：US6844456B2

  公开（公告）日：2005-01-18
• US9156876B2
  申请人：——

  公开号：US9156876B2

  公开（公告）日：2015-10-13
• [EN] ESTRONE-DERIVATIVES HAVING CYTOPROTECTIVE ACTIVITY<br/>[FR] STRUCTURES DE CYCLES AROMATIQUES MODIFIES A SUBSTITUTION HYDROXY ET A ACTIVITE CYTOPROTECTRICE
  申请人：——

  公开号：WO2002036605A9

  公开（公告）日：2002-10-17

  [EN] The present invention is directed to modified, hydroxy-bearing aromatic ring structures having cytoprotective activity. More specifically, in a first embodiment the present invention is directed to phenolic compounds, and in particular steroids (e.g., estrogens), wherein a non-fused polycyclic, hydrophobic substituent is attached to the hydroxy-substituted A-ring thereof. The present invention is further directed to a process for conferring cytoprotection to a population of cells involving the administration of the compounds.
  [FR] L'invention porte sur des structures de cycles aromatiques à substitution hydroxy et à activité cytoprotectrice, plus spécifiquement sur des composés phénoliques et plus particulièrement des stéroïdes (par exemple des oestrogènes) au cycle A à substitution hydroxy desquelles est fixé un substituant polycyclique hydrophobe non fusionné. L'invention porte en outre sur un procédé conférant la cytoprotection à une population de cellules impliquant l'administration de ces composés.
• [EN] MODIFIED, HYDROXY-SUBSTITUTED AROMATIC STRUCTURES HAVING CYTOPROTECTIVE ACTIVITY<br/>[FR] STRUCTURES DE CYCLES AROMATIQUES MODIFIES A SUBSTITUTION HYDROXY ET A ACTIVITE CYTOPROTECTRICE
  申请人：UNIV WASHINGTON

  公开号：WO2002036605A2

  公开（公告）日：2002-05-10

  The present invention is directed to modified, hydroxy-bearing aromatic ring structures having cytoprotective activity. More specifically, in a first embodiment the present invention is directed to phenolic compounds, and in particular steroids (e.g., estrogens), wherein a non-fused polycyclic, hydrophobic substituent is attached to the hydroxy-substituted A-ring thereof. The present invention is further directed to a process for conferring cytoprotection to a population of cells involving the administration of the compounds.