trimethoxybenzyl-norephedrine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trimethoxybenzyl-norephedrine
• 英文别名: N,1,2-trimethoxy-1-phenyl-1-phenylmethoxypropan-2-amine
• 化学式: C₁₉H₂₅NO₄
• 分子量: 331.412
• InChiKey: ACKZSFACBAMXMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4,5-三甲氧基苯甲醛 在 sodium borohydrid 作用下， 以 乙醇 、 水 为溶剂， 生成 trimethoxybenzyl-norephedrine
  参考文献：
  名称：

  EP1131313

  摘要：

  公开号：

文献信息

• Enantioselective alkylation of tricyclic compounds
  申请人：Schering Corporation

  公开号：US06288233B1

  公开（公告）日：2001-09-11

  Disclosed is a process for preparing a compound of the formula: wherein X1, X2, X3, X4, and X5 are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having the formula wherein X1, X2, X3, X4, and X5 are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having the formula wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase. Also disclosed is a compound having the formula:

  揭示了一种制备以下化合物的过程： 其中X1、X2、X3、X4和X5分别独立地选自H、卤素、烷基、烷氧基、芳基和芳氧基的组，R是保护基，在该过程中，具有以下公式的化合物： 其中X1、X2、X3、X4和X5如上定义，与以下物质以任意顺序处理： (a) 非亲核强碱； (b) 手性氨基醇；和 (c) 具有以下公式的化合物： 其中L是离去基团，R如上定义。通过这种过程制备的化合物是制备法尼基蛋白转移酶抑制剂的有用中间体。还揭示了具有以下公式的化合物：
• ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS
  申请人：SCHERING CORPORATION

  公开号：EP1131313B1

  公开（公告）日：2003-02-26
• US6288233B1
  申请人：——

  公开号：US6288233B1

  公开（公告）日：2001-09-11
• US6307048B1
  申请人：——

  公开号：US6307048B1

  公开（公告）日：2001-10-23
• [EN] ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS<br/>[FR] ALKYLATION ENANTIOSELECTIVE DE COMPOSES TRICYCLIQUES
  申请人：SCHERING CORP

  公开号：WO2000031064A1

  公开（公告）日：2000-06-02

  Disclosed is a process for preparing a compound of formula (I) wherein X?1, X2, X3, X4 and X5¿ are independently selected from the group consisting of H, halo, alkyl, alkoxy, aryl, and aryloxy, and R is a protecting group, in which a compound having formula (II) wherein X?1, X2, X3, X4 and X5¿ are as defined above, is treated with the following, in any sequence: (a) a non-nucleophilic strong base; (b) a chiral amino alcohol; and (c) a compound having formula (V) wherein L is a leaving group and R is as defined above. The compounds made by this process are useful intermediates for preparing compounds that are inhibitors of farnesyl protein transferase.