1-(2-fluorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-fluorophenyl)-1,4-dihydro-4-oxo-6-methylpyridazine-3-carboxylic acid
• 英文别名: 1-(2-Fluorophenyl)-6-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylic acid；1-(2-fluorophenyl)-6-methyl-4-oxopyridazine-3-carboxylic acid
• 化学式: C₁₂H₉FN₂O₃
• mdl: MFCD07343832
• 分子量: 248.213
• InChiKey: OWVLQYNNEXUSHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  70
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Chemical hybridisation of dicots
  申请人：ZENECA LIMITED

  公开号：EP0364135A2

  公开（公告）日：1990-04-18

  A method of inducing male sterility in an agricultural or horticultural dicotyledonous plant which comprises treating the plant prior to, during or post meiosis with an amount, which is effective to produce male sterility in the plant, of at least one compound of at least one compound of the formula: wherein R¹ is a carboxy group (-COOH), or an agronomically acceptable salt thereof, or alkoxycarbonyl having up to 12 carbon atoms in the alkoxy moiety; R² is phenyl or substituted phenyl having up to three substituents collectively having a total of 0 to 6 carbon atoms, the substituents being selected from alkyl, C₄H₄=forming a naphthyl group, alkoxy, phenoxy, halogen, nitro, perhaloalkyl, alkyoxyalkyl, alkoxyalkoxy, amino, alkyl- or dialkylamino, cyano, alkoxycarbonyl, sulpho, sulphonamide, alkylcarbonyl, carbamoyl, alkyl- or dialkyl carbamoyl, carboxyalkyl, alkanoyloxy, haloalkyl, alkanoylamino, alkylthio, alkylsulphinyl and alkylsulphonyl, R³ is alkyl preferably having from 1 to 4 carbon atoms and R⁴ is hydrogen, alkyl, preferably having from 1 to 4 carbon atoms, or halogen.

  一种诱导农业或园艺双子叶植物雄性不育的方法，包括在减数分裂之前、期间或之后，用一定量的至少一种式化合物处理该植物，该量的至少一种式化合物能有效地使该植物产生雄性不育： 其中 R¹ 是羧基 (-COOH)，或其农艺学上可接受的盐，或烷氧基中最多有 12 个碳原子的烷氧羰基；R² 是苯基或具有最多三个取代基的取代苯基，取代基总共具有 0 至 6 个碳原子，这些取代基选自烷基、C₄H₄= 形成萘基、烷氧基、苯氧基、卤素、硝基、过卤烷基、烷氧基烷基、烷氧基烷氧基、氨基、烷基或二烷基氨基、氰基、烷氧基羰基、R³是烷基，最好有 1 至 4 个碳原子，R⁴是氢、烷基（最好有 1 至 4 个碳原子）或卤素。
• US4345934A
  申请人：——

  公开号：US4345934A

  公开（公告）日：1982-08-24
• US4661145A
  申请人：——

  公开号：US4661145A

  公开（公告）日：1987-04-28
• US5169429A
  申请人：——

  公开号：US5169429A

  公开（公告）日：1992-12-08