2-(2-fluorenyl)-4,5-bis(4-fluorophenyl)imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(2-fluorenyl)-4,5-bis(4-fluorophenyl)imidazole
• 英文别名: 2-(9H-fluoren-2-yl)-4,5-bis(4-fluorophenyl)-1H-imidazole
• 化学式: C₂₈H₁₈F₂N₂
• 分子量: 420.461
• InChiKey: AEUWADCFBYOBGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4,4'-二氟苯偶酰 、 2-氟萘烯甲醛 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 6.0h， 生成 2-(2-fluorenyl)-4,5-bis(4-fluorophenyl)imidazole
  参考文献：
  名称：

  Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation

  摘要：

  本发明涉及诱导肌母细胞或肌纤维分化为神经元细胞的化合物、包括该化合物的制药组合物、诱导神经元分化的方法以及用于识别其他有用的诱导神经元分化的化合物的筛选方法。更具体地说，涉及诱导神经元分化的化合物，包括肌母细胞或肌纤维的所有药学上可接受的异构体、盐、水合物、溶剂化合物和前药，通过用本发明的化合物处理肌母细胞和肌纤维来诱导肌母细胞和肌纤维分化为神经元细胞的方法，并且用于识别其他有用的诱导神经元分化的化合物的筛选方法，其中肌母细胞和肌纤维与本发明的化合物孵育并检测。

  公开号：

  US20070123576A1

文献信息

• 4,5-BIS(4-METHOXYPHENYL)IMIDAZOLE COMPOUND INDUCING DIFFERENTIATION OF MYOBLASTS OR MUSCLE FIBERS INTO NEURON CELLS, A PHARMACEUTICAL COMPOSITION INCLUDING SAID COMPOUND, A METHOD OF INDUCING NEURON CELLS DIFFERENTIATION AND A SCREENING METHOD FOR IDENTIFYING ADDITIONAL COMPOUND USEFUL FOR INDUCING NEURON CELLS DIFFERENTIATION
  申请人：Shin In-Jae

  公开号：US20100184097A1

  公开（公告）日：2010-07-22

  The present invention relates to 4,5-bis(4-methoxyphenyl)imidazole compound inducing differentiation of myoblasts or muscle fibers into neuron cells, a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation. More specifically, it relates to 2-2-[5-(3-chlorophenyl)]furanyl}-4,5-bis(4-methoxyphenyl)imidazole that induces differentiation of myoblasts or muscle fibers into neuron cells, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug thereof, and a pharmaceutical composition including said compound, a method of inducing neuron cells differentiation and a screening method for identifying additional compound useful for inducing neuron cells differentiation.

  本发明涉及一种4,5-双（4-甲氧基苯基）咪唑化合物，该化合物能够诱导肌母细胞或肌纤维分化为神经元细胞，以及包括该化合物的制药组合物、诱导神经元细胞分化的方法和用于鉴定其他用于诱导神经元细胞分化的有用化合物的筛选方法。更具体地，本发明涉及2-2-[5-(3-氯苯基) ]呋喃基}-4,5-双（4-甲氧基苯基）咪唑化合物，该化合物能够诱导肌母细胞或肌纤维分化为神经元细胞，包括其所有药学上可接受的异构体、盐、水合物、溶剂化合物和前药，以及包括该化合物的制药组合物、诱导神经元细胞分化的方法和用于鉴定其他用于诱导神经元细胞分化的有用化合物的筛选方法。
• US7718685B2
  申请人：——

  公开号：US7718685B2

  公开（公告）日：2010-05-18
• US7888118B2
  申请人：——

  公开号：US7888118B2

  公开（公告）日：2011-02-15
• Compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation
  申请人：Shin In-Jae

  公开号：US20070123576A1

  公开（公告）日：2007-05-31

  The present invention relates to compounds inducing differentiation of myoblasts or muscle fibers into neuron cells, pharmaceutical composition including said compounds, a method for inducing neuron differentiation and a screening method for identifying additional compounds useful for inducing neuron differentiation. More specifically, it relates to compounds that induce neuron differentiation from myoblasts or muscle fibers, all pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrugs thereof, the method of inducing differentiation of myoblasts or muscle fibers into neuron cells by treating myoblasts and muscle fibers with a compound of the present invention, whereby the myoblasts and muscle fibers differentiate into neuron cells, and the screening method for identifying additional compounds useful for inducing neuron differentiation, wherein myoblasts and muscle fibers are incubated with a compound of the present invention and detected.

  本发明涉及诱导肌母细胞或肌纤维分化为神经元细胞的化合物、包括该化合物的制药组合物、诱导神经元分化的方法以及用于识别其他有用的诱导神经元分化的化合物的筛选方法。更具体地说，涉及诱导神经元分化的化合物，包括肌母细胞或肌纤维的所有药学上可接受的异构体、盐、水合物、溶剂化合物和前药，通过用本发明的化合物处理肌母细胞和肌纤维来诱导肌母细胞和肌纤维分化为神经元细胞的方法，并且用于识别其他有用的诱导神经元分化的化合物的筛选方法，其中肌母细胞和肌纤维与本发明的化合物孵育并检测。