6-amino-2-methylthio-1-(4-chlorophenyl)-1H-pyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-amino-2-methylthio-1-(4-chlorophenyl)-1H-pyrimidin-4-one
• 英文别名: 6-amino-1-(4-chlorophenyl)-2-methylsulfanylpyrimidin-4-one
• 化学式: C₁₁H₁₀ClN₃OS
• 分子量: 267.74
• InChiKey: MARBMSCRMFIEAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-amino-2-methylthio-1-(4-chlorophenyl)-1H-pyrimidin-4-one 、 苯胺 、 溴化钾 生成 6-amino-1-(4-chlorophenyl)-2-phenylamino-1H-pyrimidin-4-one
  参考文献：
  名称：

  Novel amino substituted pyrimidinone derivatives

  摘要：

  本发明涉及新颖的氨基取代嘧啶酮衍生物，其一般式为（I），它们的衍生物，类似物，互变异构体，立体异构体，多晶型，水合物，溶剂化物，药学上可接受的盐和含有它们的药学上可接受的组合物。本发明更特别地提供了一种新的氨基取代嘧啶酮衍生物的制备方法和一般式（I）。

  公开号：

  US20030232813A1

文献信息

• [EN] NOVEL AMINO SUBSTITUTED PYRIMIDINONE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE PYRIMIDINONE AMINO-SUBSTITUES
  申请人：ORCHID CHEMICALS & PHARM LTD

  公开号：WO2003084936A2

  公开（公告）日：2003-10-16

  The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel amino substituted pyrimidinone derivatives of the general formula (I) and a method thereof.
• Novel amino substituted pyrimidinone derivatives
  申请人：ORCHID CHEMICALS & PHARMACEUTICALS LIMITED

  公开号：US20030232813A1

  公开（公告）日：2003-12-18

  The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel amino substituted pyrimidinone derivatives of the general formula (I) and a method thereof. 1

  本发明涉及新颖的氨基取代嘧啶酮衍生物，其一般式为（I），它们的衍生物，类似物，互变异构体，立体异构体，多晶型，水合物，溶剂化物，药学上可接受的盐和含有它们的药学上可接受的组合物。本发明更特别地提供了一种新的氨基取代嘧啶酮衍生物的制备方法和一般式（I）。