N-(2-methoxyethyl)-3-tosylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methoxyethyl)-3-tosylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine
• 英文别名: N-(2-methoxyethyl)-10-(4-methylphenyl)sulfonyl-5-thia-1,8,11,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),3,7,9,11-pentaen-7-amine
• 化学式: C₁₇H₁₇N₅O₃S₂
• 分子量: 403.5
• InChiKey: SVTXFCXYNLZWGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] TRIAZOLOTHIENOPYRIMIDINE COMPOUND INHIBITORS OF UREA TRANSPORTERS AND METHODS OF USING INHIBITORS<br/>[FR] COMPOSÉS INHIBITEURS TRIAZOLOTHIÉNOPYRIMIDINES DE TRANSPORTEURS D'URÉE ET PROCÉDÉS D'UTILISATION DES INHIBITEURS
  申请人：UNIV CALIFORNIA

  公开号：WO2013148813A1

  公开（公告）日：2013-10-03

  Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

  本文提供了一种小分子三唑并噻吩嘧啶化合物，可抑制溶质转运体的尿素转运活性，尤其是UT-B转运体。本文所描述的化合物可用于增加液体过载状态下的溶质清除，并用于治疗与心血管、肾脏和代谢性疾病、障碍和病况相关的顽固性水肿。
• TRIAZOLOTHIENOPYRIMIDINE COMPOUND INHIBITORS OF UREA TRANSPORTERS AND METHODS OF USING INHIBITORS
  申请人：Anderson Marc

  公开号：US20150057274A1

  公开（公告）日：2015-02-26

  Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

  本文提供了一种小分子三唑噻吩嘧啶化合物，可抑制溶质转运体，特别是UT-B转运体的尿素转运活性。本文所描述的化合物可用于在液体过载状态下增加溶质清除，并用于治疗与心血管、肾脏和代谢性疾病、紊乱和情况相关的难治性水肿。
• US9303042B2
  申请人：——

  公开号：US9303042B2

  公开（公告）日：2016-04-05
• [EN] BENZYLIDENE DERIVATIVE CHROMOPHORES FOR PHOTOREFRACTIVE COMPOSITIONS<br/>[FR] CHROMOPHORES DÉRIVÉS DE BENZYLIDÈNE POUR COMPOSITIONS PHOTORÉFRACTIVES
  申请人：NITTO DENKO CORP

  公开号：WO2013148892A1

  公开（公告）日：2013-10-03

  Described herein are benzylidene derivative chromophores that are useful in forming compositions that are photorefractive upon irradiation by multiple laser wavelengths across the visible light spectrum. Embodiments of the photorefractive composition comprise a polymer matrix and a chromophore, wherein the chromophore is represented by general formula (II), as defined herein. The photorefractive composition can be used in various optical devices.