[(1R)-1-(6-nitro-1,3-benzodioxol-5-yl)ethyl] carbonochloridate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: [(1R)-1-(6-nitro-1,3-benzodioxol-5-yl)ethyl] carbonochloridate
• 化学式: C10H8ClNO6
• 分子量: 273.62
• InChiKey: LLQGXKKNTCFHEE-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• C-3' protected monomeric nucleotides and synthesis of oligonucleotides on solid support
  申请人：——

  公开号：US20010044530A1

  公开（公告）日：2001-11-22

  Immobilized nucleotide primers of this invention include a modified nucleotide tethered to a support substrate through a linking group. In particular, the modified nucleotide is constructed such that the C-5′ end of the nucleotide is tetherable to the linking group and the protected C-3′ end is available for further controlled modification, e.g., addition of other nucleotides in specific sequences to the immobilized nucleotide primer. Additionally, the linking group is of sufficient length to allow the immobilized nucleotide primer to be used to synthesize and screen arrays of oligonucleotides, e.g., enzymatic C-3′ primer extension.

  本发明的固定核苷酸引物包括通过连接基团固定在支撑基质上的修饰核苷酸。特别是，修饰核苷酸构建为核苷酸的C-5'末端可连接到连接基团，而受保护的C-3'末端可用于进一步的受控修饰，例如，在固定的核苷酸引物中特定序列的添加其他核苷酸。此外，连接基团的长度足够长，可用于合成和筛选寡核苷酸阵列，例如，酶促C-3'引物延伸。
• Expanded pore particles and delivery methods thereof
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10933027B1

  公开（公告）日：2021-03-02

  The present invention relates to a construct including a porous core, a cargo, and a spacer disposed between the core and the cargo. In some examples, the construct further includes an outer layer composed of a lipid, a polymer, or a combination thereof. Methods of making and employing such constructs are also described herein.

  本发明涉及一种构造物，包括多孔内核、货物以及设置在内核和货物之间的间隔物。在某些实例中，该结构体还包括由脂质、聚合物或其组合构成的外层。本文还描述了制造和使用这种构造物的方法。
• 3' biased microarrays
  申请人：Erlander G. Mark

  公开号：US20050014168A1

  公开（公告）日：2005-01-20

  The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).

  本发明提供了通过表达序列的 3′部分检测核酸表达的材料和方法。本发明的实施方案包括使用由与表达序列 3′端互补的核酸探针组成的微阵列，以及使用基于定量 PCR（Q-PCR）的方法扩增在表达序列 3′端或附近发现的序列。本发明可用于检测是否存在编码特定基因产物的表达核酸（存在于 "转录组 "中的序列）。
• 3' Biased Detection of Nucleic Acids
  申请人：Erlander Mark G.

  公开号：US20090270271A1

  公开（公告）日：2009-10-29

  The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
• 3' BIASED DETECTION OF NUCLEIC ACIDS
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20160194707A1

  公开（公告）日：2016-07-07

  The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ and of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).