glutaric acid monofluorenylmethyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: glutaric acid monofluorenylmethyl ester
• 英文别名: 5-(9H-fluoren-1-ylmethoxy)-5-oxopentanoic acid
• 化学式: C₁₉H₁₈O₄
• 分子量: 310.35
• InChiKey: AKMNXFPRFUKZES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  9H-芴-1-基甲醇 、 5,5'-氧双(5-氧代戊酸) 在 2-二甲氨基吡啶 、 碳酸氢钠 作用下， 以 吡啶 为溶剂， 生成 glutaric acid monofluorenylmethyl ester
  参考文献：
  名称：

  Phosphate linked oligomers

  摘要：

  新型乙二醇化合物带有各种功能基团，用于制备寡聚物结构。乙二醇单体可以通过标准的磷酸酯键连接，包括磷硫酸酯、磷酸二酯和磷酰胺酸酯键。有用的功能基团包括核碱基以及极性基团、疏水基团、离子基团、芳香基团和/或参与氢键作用的基团。

  公开号：

  US05886177A1

文献信息

• Method of treating cancer
  申请人：——

  公开号：US20020042375A1

  公开（公告）日：2002-04-11

  The present invention relates to methods of treating cancer using a combination of a compound which is a PSA conjugate and an NSAID compound, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is a PSA conjugate and an NSAID compound. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种PSA共轭物和一种NSAID化合物的组合治疗癌症的方法，该方法包括向所述哺乳动物施用至少两种治疗剂量，所述治疗剂量选自一组包括一种PSA共轭物和一种NSAID化合物，所述治疗剂量可以顺序给药或同时给药。该发明还涉及制备这种组合物的方法。
• Conjugates useful in the treatment of prostate cancer
  申请人：——

  公开号：US20030133927A1

  公开（公告）日：2003-07-17

  Chemical conjugates which comprise an oligopeptide covalently bonded, either directly or through a chemical linker, to a peptide or small molecule that binds to an anti-apoptotic Bcl-2 family protein, inhibits the expression of the Bcl-2 family protein, or inhibits the function of the Bcl-2 family protein. Such a peptide or small molecule that binds to an anti-apoptotic Bcl-2 family protein, inhibits the expression of the Bcl-2 family protein, or inhibits the function of the Bcl-2 family protein may be conveniently referred to as a therapeutic agent. The oligopeptides are chosen from oligomers that are selectively recognized by the free prostate specific antigen (PSA) and are capable of being proteolytically cleaved by the enzymatic activity of the free prostate specific antigen.

  化学共轭物是由寡肽与与抗凋亡Bcl-2家族蛋白结合、抑制Bcl-2家族蛋白表达或抑制Bcl-2家族蛋白功能的肽或小分子，通过化学连接剂直接共价键合而成。这样的肽或小分子可方便地称为治疗剂。寡肽是从被游离的前列腺特异性抗原（PSA）选择性识别的寡聚体中选择的，并能够被游离的前列腺特异性抗原酶解活性所切割。
• Monomeric diols, phosphate linked oligomers formed therefrom and processes for preparing
  申请人：——

  公开号：US20030065146A1

  公开（公告）日：2003-04-03

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，用于制备寡聚体结构。乙二醇单体可以通过标准的磷酸酯和磷酸硫酯键连接。有用的功能基团包括核苷碱以及极性基团，疏水基团，离子基团，芳香基团和/或参与氢键的基团。
• Phosphate linked oligomers formed of monomeric diols and processes for preparing same
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06448373B1

  公开（公告）日：2002-09-10

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，可用于制备寡聚物结构。乙二醇单体可以通过标准的磷酸酯键和磷酸硫酯键连接起来。有用的功能基团包括核碱基以及极性基团、亲水基团、离子基团、芳香基团和/或参与氢键的基团。
• PROCESS FOR PREPARING PEPTIDE INTERMEDIATES
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1226158B1

  公开（公告）日：2003-07-02