2-naphthylacyl bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-naphthylacyl bromide
• 英文别名: Naphthalene-2-carbonyl bromide
• 化学式: C₁₁H₇BrO
• 分子量: 235.08
• InChiKey: AMYLWDZBDUEFCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-[(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl]-1H-benzo[d]imidazole 、 2-naphthylacyl bromide 以 丙酮 为溶剂， 以96%的产率得到1-[(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl]-3-[2-(naphthalen-2-yl)-2-oxoethyl]-1H-benzo[d]imidazol-3-ium bromide
  参考文献：
  名称：

  1,4-苯并二恶烷与咪唑鎓盐类新型杂化化合物的合成及抗肿瘤活性

  摘要：

  设计并制备了一系列1,4-苯并二恶烷与咪唑鎓盐的新型杂化化合物。这些化合物在体外针对一组人类肿瘤细胞系（K562、SMMC-7721 和 A-549）进行了评估。构效关系结果表明，2-甲基-苯并咪唑或 5,6-二甲基-苯并咪唑环和 4-苯基苯甲酰基取代基取代咪唑基-3-位对促进细胞毒活性至关重要。特别是，化合物25被发现是最有效的化合物，对三种人类肿瘤细胞系的 IC 50值为 1.06–8.31 μM，并对 K562 和 SMMC-7721 细胞表现出更高的选择性，IC 50值比顺铂低 4.5 和 4.7 倍。此外，化合物25通过诱导 SMMC-7721 细胞中的 G0/G1 细胞周期停滞和细胞凋亡来抑制细胞增殖。

  DOI：

  10.1002/ardp.202200109
• 作为产物：
  描述：

  2-萘甲酸 在 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 以 1,4-二氧六环 为溶剂， 以95%的产率得到2-naphthylacyl bromide
  参考文献：
  名称：

  Froeyen, Paul, Phosphorus, Sulfur and Silicon and the Related Elements, 1995, vol. 102, # 1-4, p. 253 - 260

  摘要：

  DOI：

文献信息

• [EN] METHOD OF CONVERTING ALCOHOL TO HALIDE<br/>[FR] PROCÉDÉ DE CONVERSION D'UN ALCOOL EN HALOGÉNURE
  申请人：UNIV SAARLAND

  公开号：WO2016202894A1

  公开（公告）日：2016-12-22

  The present invention relates to a method of converting an alcohol into a corresponding halide. This method comprises reacting the alcohol with an optionally substituted aromatic carboxylic acid halide in presence of an N-substituted formamide to replace a hydroxyl group of the alcohol by a halogen atom. The present invention also relates to a method of converting an alcohol into a corresponding substitution product. The second method comprises: (a) performing the method of the invention of converting an alcohol into the corresponding halide; and (b) reacting the corresponding halide with a nucleophile to convert the halide into the nucleophilic substitution product.

  本发明涉及一种将醇转化为相应卤化物的方法。该方法包括在N-取代甲酰胺的存在下，将醇与可选择取代的芳香羧酸卤化物反应，以通过卤原子取代醇的羟基。本发明还涉及一种将醇转化为相应取代产物的方法。第二种方法包括：(a)执行将醇转化为相应卤化物的本发明方法；以及(b)将相应卤化物与亲核试剂反应，将卤化物转化为亲核取代产物。
• Fungicidal oxime carbamates
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0397345A1

  公开（公告）日：1990-11-14

  A method of controlling plant diseases, especially fungi, using oxime carbamates and analogs thereof and novel compounds within the class. Reason: Rule 8.1.i PCT.

  一种使用肟基氨基甲酸酯及其类似物以及该类中的新颖化合物来控制植物病害，尤其是真菌的方法。 原因：PCT规则8.1.i。
• METHOD FOR PRODUCING CYCLIC SULFONIC ACID ESTER AND INTERMEDIATE THEREOF
  申请人：Kuramoto Ayako

  公开号：US20120130089A1

  公开（公告）日：2012-05-24

  The present invention is directed to provide an efficient production method which is capable of not only obtaining a cyclic sulfonic acid ester (sultone) at low cost and in high yield, but also the sulfonic acid ester (sultone) stably even in a commercial scale. The present invention relates to a method for producing hydroxysultone comprising a first step where a diol having a specified structure and a thionyl halide are reacted to obtain a cyclic sulfite having a specified structure, and a second step where the cyclic sulfite is reacted with water or/and alcohol; a method for producing an unsaturated sultone having a specified structure comprising a third step where a hydroxylsultone having a specified structure is reacted with an acid halide or an acid anhydride to obtain an intermediate, subsequently the intermediate is treated with a base; as well as a cyclic sulfite having a specified structure.

  本发明旨在提供一种高效的生产方法，该方法不仅能够以低成本和高产率获得环状磺酸酯（磺酮），而且能够在商业规模下稳定地生产磺酸酯（磺酮）。本发明涉及一种生产羟基磺酮的方法，包括第一步，其中将具有特定结构的二元醇和硫酰卤反应，以获得具有特定结构的环状亚磺酸酯，以及第二步，其中将环状亚磺酸酯与水或/和醇反应；一种生产具有特定结构的不饱和磺酮的方法，包括第三步，其中将具有特定结构的羟基磺酮与酸卤或酸酐反应，以获得中间体，随后用碱处理中间体；以及具有特定结构的环状亚磺酸酯。
• Process for preparing acylated esters of hydroxy carboxylates
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0002872A1

  公开（公告）日：1979-07-11

  A process for esterifying and acylating hydroxycarboxylate compounds in an organonitrile reaction medicine comprising the steps of contacting said compounds with an esterification agent-and thereafter acylating by adding an acylating agent to the reaction medium.

  一种在有机腈反应药剂中对羟基羧酸化合物进行酯化和酰化的工艺，包括以下步骤：将所述化合物与酯化剂接触，然后通过向反应介质中添加酰化剂进行酰化。
• POLYCARBONATE RESIN
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2011810A1

  公开（公告）日：2009-01-07

  The object of the present invention is to provide a polycarbonate resin having an extremely narrow molecular weight distribution, good flowability when melting, and particularly extremely good flowability when melting that does not depend on shear rate. The present invention relates to a polycarbonate resin, characterized in that a value obtained by dividing difference between a logarithmic value log MV9.12 of a melt viscosity (Pa·s) measured at shear rate of 9.12 sec-1 and a logarithmic value log MV1624 of a melt viscosity (Pa·s) measured at shear rate of 1824 sec-1, with a capillary rheometer having a die diameter of 1 mmφ and an effective length of 30 mmL, by a viscosity average molecular weight Mv calculated by the following equations, viscosity difference/molecular weight ratio, is 2.0×10-5 or less. ηsp/C=η×1+0.28⁢ηsp η=1.23×10-4×Mv0.83 (In the above equations, ηsp is a specific viscosity measured at 20°C with respect to a methylene chloride solution of a polycarbonate resin, C is a polycarbonate resin concentration of the methylene chloride solution, and C=0.6 g/dl).

  本发明的目的是提供一种聚碳酸酯树脂，其分子量分布极窄，熔融时流动性好，特别是熔融时流动性极好，且不依赖于剪切速率。本发明涉及一种聚碳酸酯树脂，其特征在于在剪切速率为 9.ηsp/C=η×1+0.28ηspη=1.23×10-4×Mv0.83。 (在上述公式中，ηsp 是在 20°C 时测得的聚碳酸酯树脂二氯甲烷溶液的比粘度，C 是二氯 甲烷溶液中聚碳酸酯树脂的浓度，C=0.6 g/dl）。