N,N-diallylpyridin-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-diallylpyridin-2-amine
• 英文别名: N,N-bis(prop-2-enyl)pyridin-2-amine
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.246
• InChiKey: AOLCGYKUKJGCFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-diallylpyridin-2-amine 在 palladium on activated charcoal 甲烷磺酸 作用下， 以 乙醇 为溶剂， 生成 1-(吡啶-2-氨基)-2-丙醇
  参考文献：
  名称：

  Allyl amines as ammonia equivalents in the preparation of anilines and heteroarylamines

  摘要：

  A series of anilines and heteroarylamines were synthesized in moderate to excellent yields by palladium catalyzed cross coupling reaction of aryl or heteroaryl halides with allyl-or N,N-diallylamine followed by deallylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10877-2
• 作为产物：
  描述：

  2-羟基吡啶 在 4-二甲氨基吡啶 、 lithium chloro-isopropyl-magnesium chloride 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 生成 N,N-diallylpyridin-2-amine
  参考文献：
  名称：

  酰胺化氨基磷酸二氨基磷酸酯取代的吡啶和相关的N-杂环

  摘要：

  各种二氨基磷酸酯基取代的吡啶，喹啉，并用镁酰胺喹喔啉的胺化- [R 2个8小时内于室温下NMgCl·LiCl前进。几种药物活性胺是用于该胺化程序的合适底物，并且还制备了抗组胺的三烯胺。另外，使用TMPMgCl·LiCl（TMP = 2,2,6,6-四甲基哌啶基）或TMP 2 Mg·2LiCl对几种杂环二氨基氨基磷酸酯进行定向邻位金属化（D o M），然后在胺化步骤之前进行亲电子官能化，导致邻官能化的胺化N-杂环。

  DOI：

  10.1021/acs.orglett.8b03698

文献信息

• PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS
  申请人：Tewari Neera

  公开号：US20110224426A1

  公开（公告）日：2011-09-15

  The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P 1 is hydrogen or a carboxyl protecting group, P 3 is hydrogen or a hydroxyl protecting group, R 1 is C 1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P 2 is hydrogen or an amino protecting group, R 2 and R 3 may be same or different and are hydrogen, C 1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X 1 is O or S, or its stereoisomers, or salts thereof.

  本发明涉及一种制备式(I)碳青霉烯化合物的工艺，其中P1为氢或羧酸保护基团，P3为氢或羟基保护基团，R1为C1-3烷基，A选自以下组：a)式(II)，b)式(III)，c)式(IV)，d)式(V)，e)式(VI)，f)式(VII)，其中P2为氢或氨基保护基团，R2和R3相同或不同，为氢，C1-5烷基，可选地取代的芳基或可选地取代的杂芳基，X1为O或S，或其立体异构体，或其盐。
• [EN] PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBONYLCHLORIDE COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS 1H-PYRAZOLE-5-CARBONYLCHORURES N-SUBSTITUÉS
  申请人：BASF SE

  公开号：WO2013024007A1

  公开（公告）日：2013-02-21

  The present invention relates to a process for preparing an N-substi- tuted 1 H-pyrazole-5-carbonylchloride compound of the formula (I) comprising the steps of i) deprotonating a compound of the formula (II) with a base selected from lithium-organic base having a carbon or nitrogen bound lithium or with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a chlorocarbonylation by reacting it with a reagent selected from the group consisting of phosgene or a phosgene equivalent, to obtain a compound of formula (I).

  本发明涉及一种制备式(I)N-取代1H-吡唑-5-羰基氯化物的过程，包括以下步骤：i) 用选择自碳或氮与锂结合的有机锂碱或碳与镁结合的有机镁碱的碱去质子化式(II)化合物；和ii) 将步骤(i)中获得的产物经氯羰基化反应，与磷酰氯或磷酰氯等效物中选择的试剂反应，以获得式(I)化合物。
• PHOSPHOLE COMPOUND
  申请人：NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

  公开号：US20190264031A1

  公开（公告）日：2019-08-29

  A phosphole compound represented by the formula (wherein Ar 1 and Ar 2 are the same or different, and represent an optionally substituted aromatic hydrocarbon ring or an optionally substituted heteroaromatic ring; Ar 3 represents a divalent π-conjugated unit; R 1 represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; R 2 and R 3 are the same or different, and represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heteroaryl group; and Z represents a reactive group) can provide a fluorescent dye capable of maintaining a high fluorescence quantum yield irrespective of solvent polarity, and providing an improved fluorescence quantum yield and light resistance even in environments containing large amounts of water.

  一个由以下公式表示的磷杂环化合物 （其中Ar1和Ar2相同或不同，表示一个可选择取代的芳香烃环或一个可选择取代的杂环烃环；Ar3表示一个二价π-共轭单元；R1表示一个可选择取代的烷基团、一个可选择取代的环烷基团、一个可选择取代的芳基团或一个可选择取代的杂芳基团；R2和R3相同或不同，表示一个氢原子、一个可选择取代的烷基团、一个可选择取代的环烷基团、一个可选择取代的芳基团或一个可选择取代的杂芳基团；Z表示一个反应性基团）可以提供一种荧光染料，能够保持高荧光量子产率，不受溶剂极性影响，并且在含有大量水的环境中也能提供改善的荧光量子产率和耐光性。
• Amination of 2‐Pyridinesulfonic and 8‐Quinolinesulfonic Acids with Magnesium Amides
  作者：Moritz Balkenhohl、Vasiliki Valsamidou、Paul Knochel

  DOI：10.1002/ejoc.201900057

  日期：2019.9

  The amination of 2‐pyridine‐ and 8‐quinolinesulfonic acids using magnesium amides is reported. Various amides reacted with N‐heterocyclic sulfonic acids, leading to aminopyridines and aminoquinolines in up to 98 % yield. Various amines important in medicinal chemistry, such as the antidepressant amoxapine, were suitable for these aminations.

  据报道，使用酰胺化氨基的2-吡啶基和8-喹啉磺酸被胺化。各种酰胺与N-杂环磺酸反应，生成氨基吡啶和氨基喹啉，产率高达98％。在药物化学中很重要的各种胺，例如抗抑郁药阿莫沙平，都适合于这些胺化反应。
• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED OCTANOYL AMIDES<br/>[FR] PROCEDE DE FABRICATION D'OCTANOYLAMIDES SUBSTITUES
  申请人：SPEEDEL PHARMA AG

  公开号：WO2002008172A1

  公开（公告）日：2002-01-31

  Compounds of formula (XII), are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is reacted with an amine to form a carboxamide, the halogen is replaced with azide, if necessary after the introduction of a hydroxy protecting group, the resulting azide is converted to a lactone, the lactone is amidated and then the azide converted to the amine group, in order to obtain compounds of formula (I) or a salt thereof.

  公式（XII）的化合物在 lactonization 过程中，5 位同时被卤化，4 位被羟基化，卤代内酯与胺反应形成羧酰胺，卤素被叠氮基取代，如有必要，在引入羟基保护基团后，将所得叠氮化物转化为内酯，内酯进行酰胺化，然后将叠氮化物转化为胺基团，以获得公式（I）的化合物或其盐。