2-[(2R)-butan-2-yl]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(2R)-butan-2-yl]aniline
• 化学式: C₁₀H₁₅N
• 分子量: 149.23
• InChiKey: XAGPXEVNCJHXCL-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Producing optically active amino compounds
  申请人：Kaneka Corporation

  公开号：US20020192786A1

  公开（公告）日：2002-12-19

  To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.

  提供一种通过微生物酶高效、低成本地制备主要含有(R)-氨基化合物的手段；一种具有立体选择性转氨酶活性的多肽，适用于上述制备方法；以及编码该多肽的DNA。一种制备光学活性氨基化合物的方法，其特征在于，在存在氨基供体——一种初级胺的情况下，通过作用转氨酶对氨基受体进行立体选择性转氨，将酮化合物转化为目标化合物；一种包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA；以及从属于芽孢杆菌属的微生物培养物中获得的具有立体选择性转氨酶活性的多肽。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINO COMPOUNDS
  申请人：Kaneka Corporation

  公开号：EP0987332A1

  公开（公告）日：2000-03-22

  A process for efficiently producing optically active amino compounds, mainly (R)-amino compounds, at a low cost by means of a microbial enzyme; a polypeptide suitable for use in the production process and having a stereoselective transaminase activity; and a DNA coding for the polypeptide. The process is characterized by comprising causing a transaminase to act on a ketone compound as an amino acceptor in the presence of a primary amine as an amino donor to stereoselectively transfer the amino group to thus obtain an optically active amino compound. The DNA contains a base sequence coding for a polypeptide having a stereoselective transaminase activity. The polypeptide can be obtained by incubating a microorganism belonging to the genus Arthrobacter.

  一种利用微生物酶以低成本高效生产光学活性氨基化合物（主要是(R)-氨基化合物）的工艺；一种适用于该生产工艺并具有立体选择性转氨基酶活性的多肽；以及一种为该多肽编码的DNA。该工艺的特点是包括使转氨酶在作为氨基供体的伯胺存在下作用于作为氨基受体的酮化合物，立体选择性地转移氨基，从而获得光学活性氨基化合物。DNA 含有编码具有立体选择性转氨酶活性的多肽的碱基序列。该多肽可通过培养属于节杆菌属的微生物获得。
• DNA encoding a polypeptide having stereoselective transaminase activity, and transformants comprising said DNA
  申请人：KANEKA CORPORATION

  公开号：EP0987332B1

  公开（公告）日：2009-08-19
• US7169592B2
  申请人：——

  公开号：US7169592B2

  公开（公告）日：2007-01-30
• US8318733B2
  申请人：——

  公开号：US8318733B2

  公开（公告）日：2012-11-27