4-amino-2,6-diethylphenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-2,6-diethylphenol
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: APCYWMCOXOKKCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-噻吩甲酸 、 4-amino-2,6-diethylphenol 、 氯磷酸二乙酯 在 碳酸氢钠 、 三乙胺 作用下， 以 乙腈 为溶剂， 生成 4-(thien-2-ylcarbonyl)amino-2,6-diethylphenol
  参考文献：
  名称：

  4-aminophenol derivatives and processes for preparing the same

  摘要：

  揭示了一种公式为：##STR1##（其中R.sup.1和R.sup.2分别代表较低的烷基基团，Y代表单键合臂，较低的烷基烯基团或较低的烯基烯基团，R.sup.3代表一硫代吡咯基团或吡咯基团，也可以用较低烷基基团取代；苯并噻吩基团，吲哚基团；或被1至2个从较低烷氧基和较低烷酰氧基中选择的基团取代的苯酚基团；或Y-R.sup.3代表整体地具有6至9个碳原子的烷基基团；或具有2或3个双键的5至14个碳原子的烃基团）或其药理学上可接受的盐，以及其制备方法。

  公开号：

  US05047555A1

文献信息

• Formamidoxime derivatives with fungicidal and insecticidal activity
  申请人：NIPPON SODA CO., LTD.

  公开号：EP0132881A1

  公开（公告）日：1985-02-13

  A compound having the formula wherein X represents same or different substituent(s) selected from a group consisting of halogen, nitro, cyano, formyl, C2~8 alkylcarbonyl, carboxy, C2~8 alkoxycarbonyl, C3~8 alkenyloxycarbonyl, C3~8 alkynyloxycarboxyl, carbamoyl, C2-6 alkylcarbamoyl, hetrocyclic radical containing oxygen, and a satulated or unsatulated C1~6 hydrocarbon radical which may be substituted by cyano, hydroxy, halogen, C1~6 alkoxy, Ci-6 alkoxy substituted by C1~6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, C3-6 alkynyloxycarbonyloxy, C16 alkylthio, C1~6 alkylsulfinyl, C1~6 alkylsulfonyl, amino substituted by C1~6 alkyl, hydroxyimino, C1~6 alkoxyimino and/or C2~8 or alkoxycarbonyl; and -B- represents -0-, -S-, -SO-, -SO2- or (R' is hydrogen or C1~6 alkyl); and Y represents hydrogen or same or different substituent(s) consisting of satulated or unsaturated C1-6 hydrocarbon radicals which may be substituted by halogen, cyano, C3-6 cycloalkyl, C2~8 alkylcarbonyloxy, C2-8 alkylcarbonyl, C2-8 alkoxycarbonyl, hydroxy, C1~6 alkoxy, C1~6 alkylthio, ureido or heterocyclic radical containing oxygen; and a part of (̵B-Y)n represents bi-substitutive modified radical(̵B-Y)̵ selected from a group consisting of C1~3 alkylenedioxy which may be substituted by Ci-6 alkoxy, -O-(CH2)l-O(CH2)l'- and -O-(CH2)I-O-CO-(each of and I' is a integer from 1 to 3); and each of m and n represents an integer from 0 to 5 with the proviso that 0≤m+n≤5 and the substituent shown above takes "one", except the bisubstitutive modified -B-Y type rad- ica(̵-B-Y)̵which takes "two"; and R represents a substituent selected from a group consisting of satulated or unsatulated C1~18 hydrocarbon radicals which may be substituted by halogen, cyano, C1~6 alkoxy, C1~6 alkylthio, Ci-6 alkoxycarbonyl; and with the proviso that "C number - number" represents the range of total carbon number of the substituent or radical directly following thereto; or a salt thereof with an organic or inorganic acid; or a complex thereof with a metal salt; and a fungicide, and insecticide and/or an acaricide containing said compound, salt, and/or complex.

  具有以下式子的化合物 其中 X 代表相同或不同的取代基，选自由卤素、硝基、氰基、甲酰基、C2~8 烷基羰基、羧基、C2~8 烷氧基羰基、C3~8 烯氧基羰基、C3~8 烷炔氧基羰基、氨基甲酰基、C2~6 烷基氨基甲酰基、含氧杂环基组成的组、和饱和或未饱和的 C1~6 烃基，可被氰基、羟基、卤素、C1~6 烷氧基、被 C1~6 烷氧基取代的 Ci-6 烷氧基、C2~6 烯氧基、C2~6 烷炔氧基、C3~6 烷炔氧基羰氧基、C16烷硫基、C1~6 烷基亚磺酰基、C1~6 烷基磺酰基、被 C1~6 烷基取代的氨基、羟基亚氨基、C1~6 烷氧基亚氨基和/或 C2~8 或烷氧基羰基取代；和-B-代表-0-、-S-、-SO-、-SO2-或 (R'是氢或 C1~6 烷基）；以及 Y 代表氢或由饱和或不饱和 C1-6 烃基组成的相同或不同的取代基，可被卤素、氰基、 C3-6 环烷基、C2~8 烷基羰氧基、C2-8 烷基羰基、C2-8 烷氧基羰基、羟基、C1~6 烷氧基、C1~6 烷硫基、脲基或含氧杂环基取代；(̵B-Y)n的一部分代表双取代修饰基(̵B-Y)̵，该修饰基选自由 C1~3烷二氧基（可被Ci-6烷氧基取代）、-O-(CH2)l-O(CH2)l'-和-O-(CH2)I-O-CO-（其中每个和I'都是1~3的整数）组成的组；m和n各代表0至5的整数，但0≤m+n≤5，上述取代基取 "一"，但双取代修饰的-B-Y型rad- ica(̵-B-Y)̵ 取 "二 "除外；以及 R 代表选自饱和或非饱和 C1~18 烃基组成的取代基，可被卤素、氰基、C1~6 烷氧基、C1~6 烷硫基、Ci-6 烷氧羰基取代；但 "C 数-数 "代表取代基或其直接后面的基的总碳数范围； 或其与有机酸或无机酸的盐；或其与金属盐的络合物；以及含有上述化合物、盐和/或络合物的杀真菌剂、杀虫剂和/或杀螨剂。
• 4-Aminophenol derivatives and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0374048A1

  公开（公告）日：1990-06-20

  There are disclosed a 4-aminophenol derivative of the formula: (wherein R¹ and R² each represent a lower alkyl group, Y represents a single bonding arm, a lower alkylene group or a lower alkenylene group, R³ represents a thienyl group or pyrrolyl group which may be also substituted with a lower alkyl group; benzothienyl group, indolyl group; or a phenyl group which is substituted with 1 to 2 groups selected from a lower alkoxy group and a lower alkanoyloxy group; or Y-R³ represents integrally an alkyl group with 6 to 9 carbon atoms; or a hydrocarbon group with 5 to 14 carbon atoms having 2 or 3 double bonds) or a pharmacologically acceptable salt thereof, and pro­cesses for preparing the same.

  公开了一种4-氨基苯酚衍生物，其式如下 (其中R¹和R²各代表一个低级烷基，Y代表一个单键臂、一个低级亚烷基或一个低级亚烯基，R³代表一个噻吩基或吡咯基，它们也可被一个低级烷基取代；苯并噻吩基、吲哚基；或被 1 至 2 个选自低级烷氧基和低级烷酰氧基的基团取代的苯基；或 Y-R³ 整体代表 6 至 9 个碳原子的烷基；或具有 2 或 3 个双键的 5 至 14 个碳原子的烃基）或其药理学上可接受的盐，以及制备这些盐的工艺。
• US4517005A
  申请人：——

  公开号：US4517005A

  公开（公告）日：1985-05-14
• US5047555A
  申请人：——

  公开号：US5047555A

  公开（公告）日：1991-09-10
• 4-aminophenol derivatives and processes for preparing the same
  申请人：Tanabe Seiyaku Co., Ltd.

  公开号：US05047555A1

  公开（公告）日：1991-09-10

  There are disclosed a 4-aminophenol derivative of the formula: ##STR1## (wherein R.sup.1 and R.sup.2 each represent a lower alkyl group, Y represents a single bonding arm, a lower alkylene group or a lower alkenylene group, R.sup.3 represents a thienyl group or pyrrolyl group which may be also substituted with a lower alkyl group; benzothienyl group, indolyl group; or a phenol group which is substituted with 1 to 2 groups selected from a lower alkoxy group and a lower alkanoyloxy group; or Y-R.sup.3 represents integrally an alkyl group with 6 to 9 carbon atoms; or a hydrocarbon group with 5 to 14 carbon atoms having 2 or 3 double bonds) or a pharmacologically acceptable salt thereof, and processes for preparing the same.

  揭示了一种公式为：##STR1##（其中R.sup.1和R.sup.2分别代表较低的烷基基团，Y代表单键合臂，较低的烷基烯基团或较低的烯基烯基团，R.sup.3代表一硫代吡咯基团或吡咯基团，也可以用较低烷基基团取代；苯并噻吩基团，吲哚基团；或被1至2个从较低烷氧基和较低烷酰氧基中选择的基团取代的苯酚基团；或Y-R.sup.3代表整体地具有6至9个碳原子的烷基基团；或具有2或3个双键的5至14个碳原子的烃基团）或其药理学上可接受的盐，以及其制备方法。