2-[[(2R)-pyrrolidin-2-yl]methoxy]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-[[(2R)-pyrrolidin-2-yl]methoxy]acetic acid
• 化学式: C₇H₁₃NO₃
• 分子量: 159.18
• InChiKey: XKWHMSPACVTMTA-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US20160257712A1

  公开（公告）日：2016-09-08

  Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.