(4S,5S)-3-tert-butyloxycarbonyl-2,2-dimethyl-5-(2-chloroethyl)-4-isobutyloxazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S,5S)-3-tert-butyloxycarbonyl-2,2-dimethyl-5-(2-chloroethyl)-4-isobutyloxazolidine
• 英文别名: tert-butyl (4S,5S)-5-(2-chloroethyl)-2,2-dimethyl-4-(2-methylpropyl)-1,3-oxazolidine-3-carboxylate
• 化学式: C₁₆H₃₀ClNO₃
• 分子量: 319.872
• InChiKey: ARPOYDQZGJFCHS-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4S,5S)-3-tert-butyloxycarbonyl-2,2-dimethyl-5-(2-chloroethyl)-4-isobutyloxazolidine 生成 (4S,5S)-3-(tert-butyloxycarbonyl)-2,2-dimethyl-5-ethenyl-4-(2-methylpropyl)oxazolidine
  参考文献：
  名称：

  KOIKE, YUTAKA;NAKANO, MASATO;ATSUUMI, SHUGO;TANAKA, SEIICHI;MORISHIMA, HA+

  摘要：

  DOI：
• 作为产物：
  描述：

  (4S,5S)-N-Boc-2,2-dimethyl-5-(2-hydroxyethyl)-4-(2-methylpropyl)-1,3-oxazolidine 生成 (4S,5S)-3-tert-butyloxycarbonyl-2,2-dimethyl-5-(2-chloroethyl)-4-isobutyloxazolidine
  参考文献：
  名称：

  KOIKE, YUTAKA;NAKANO, MASATO;ATSUUMI, SHUGO;TANAKA, SEIICHI;MORISHIMA, HA+

  摘要：

  DOI：

文献信息

• 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：EP0264106A2

  公开（公告）日：1988-04-20

  A 5-substituted amino-4-hydroxy-pentanoic acid derivative having the formula: wherein R¹ is a hydrogen atom, a lower alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyloxycarbonyl group or a lower alkanoyl group which may be substituted by from one to three substituents selected from the group consisting of an amino group, a hydroxyl group, a carboxyl group, an aryloxy group, an aralkyloxycarbonylamino group, a lower alkoxycarbonylamino group wherein each of X¹ and X² which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group, or X¹ and X² form together with the adjacent nitrogen atom a 5- or 6-membered heterocyclic group which may further contain a hereto atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom which may further contain a double bond in its carbon chain, each of R², R³ and R⁵ which may be the same or different is a hydrogen atom, a lower alkyl group or a residue of an acidic, neutral or basic amino acid, R⁴ is a hydrogen atom or a lower alkyl group, R⁶ is a lower alkyl, cycloalkyl, cycloalkylalkyl or aralkyl group which is substituted by one or two hydroxyl groups, R⁷ is a hydroxyl group, a -OY group wherein Y is a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxyalkyl group, a lower alkanoyloxyalkyl group, a lower alkoxycarbonyloxyalkyl group or a 1-phthalidyl group, wherein each of Y¹ and Y² which may be the same or different is a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group or a cycloalkyl group, or Y¹ and Y² form together with the adjacent nitrogen atom 5- or 5-membered heterocyclic group which may further contain a hereto atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, and each of n and m which may be the same or different is 0 or 1.

  5-取代氨基-4-羟基戊酸衍生物，其式如下 其中 R¹为氢原子、低级烷氧基羰基、芳氧基羰基、芳烷氧基羰基或低级烷酰基，该低级烷酰基可被选自氨基、羟基、羧基、芳氧基、芳烷氧基羰基氨基、低级烷氧基羰基氨基所组成的组中的一至三个取代基所取代 其中 X¹ 和 X² 可相同或不同，各自为氢原子、低级烷基、芳基或芳烷基，或 X¹ 和 X² 与邻近的氮原子一起形成 5 或 6 元杂环基团，该杂环基团可进一步包含一个从氮原子、氧原子和硫原子组成的组中选出的同族原子，该杂环基团可进一步在其碳链中包含一个双键，R²、R³ 和 R⁵ 可相同或不同，各自为氢原子、R⁴ 是氢原子或低级烷基，R⁶ 是被一个或两个羟基取代的低级烷基、环烷基、环烷基烷基或芳烷基、R⁷ 是羟基、-OY 基团，其中 Y 是低级烷基、芳基、芳烷基、低级烷氧基烷基、低级烷酰氧基烷基、低级烷氧羰氧基烷基或 1-邻苯二甲酰基、 其中Y¹和Y²可以相同或不同，各自为氢原子、低级烷基、芳基、芳烷基或环烷基，或Y¹和Y²与相邻的氮原子一起形成5元或5元杂环基团，该杂环基团可进一步包含一个从氮原子、氧原子和硫原子组成的组中选出的同位原子，且n和m可以相同或不同，各自为0或1。
• KOIKE, YUTAKA;NAKANO, MASATO;ATSUUMI, SHUGO;TANAKA, SEIICHI;MORISHIMA, HA+
  作者：KOIKE, YUTAKA、NAKANO, MASATO、ATSUUMI, SHUGO、TANAKA, SEIICHI、MORISHIMA, HA+

  DOI：——

  日期：——
• US4851387A
  申请人：——

  公开号：US4851387A

  公开（公告）日：1989-07-25