2,3-dihydro-5-methoxy-6-hydroxy-7-methyl-benzofuran

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 2,3-dihydro-5-methoxy-6-hydroxy-7-methyl-benzofuran
• 英文别名: 5-Methoxy-7-methyl-2,3-dihydro-1-benzofuran-6-ol
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: ASAKKQIVHWINRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3,9,4-tetrahydro-5,5-bis(methoxy)-6-one-7-methyl-benzofuran 以 溶剂黄146 为溶剂， 反应 2.0h， 以36%的产率得到2,3-dihydro-5-methoxy-6-hydroxy-7-methyl-benzofuran
  参考文献：
  名称：

  Aromatic ring synthesis by 1,3-Michael-Claisen annulation: Formation of dihydrobenzofurans and tetrahydrochromans from α-methylene γ-butyrolactone and δ-valerolactone

  摘要：

  Substituted dihydrobenzofurans and tetrahydrochromans have been prepared from respectively alpha-methylene-gamma-butyrolactone: and delta-valerolactone via a 1,3-Michael-Claisen reaction from two 3-carbon units, 1,1-bis-(methylthio)-2-propanone or butanone, and an alpha-methylene lactone.

  DOI：

  10.1016/0040-4020(95)00531-c

文献信息

• US5523319A
  申请人：——

  公开号：US5523319A

  公开（公告）日：1996-06-04
• Aromatic ring synthesis by 1,3-Michael-Claisen annulation: Formation of dihydrobenzofurans and tetrahydrochromans from α-methylene γ-butyrolactone and δ-valerolactone
  作者：Guy Solladié、Dominique Boeffel、Jean Maignan

  DOI：10.1016/0040-4020(95)00531-c

  日期：1995.8

  Substituted dihydrobenzofurans and tetrahydrochromans have been prepared from respectively alpha-methylene-gamma-butyrolactone: and delta-valerolactone via a 1,3-Michael-Claisen reaction from two 3-carbon units, 1,1-bis-(methylthio)-2-propanone or butanone, and an alpha-methylene lactone.