N-(2-methyl-benzyl)-phthalamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-methyl-benzyl)-phthalamic acid
• 英文别名: N-o-Tolubenzyl-phthalimidsaeure；N-(2-Methyl-benzyl)-phthalamidsaeure；Phthalsaeure-mono-o-tolubenzylamid；2-(2-methylbenzylcarbamoyl)benzoic acid；2-{[(2-Methylbenzyl)amino]carbonyl}benzoic acid；2-[(2-methylphenyl)methylcarbamoyl]benzoic acid
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: RJWQVKJGHYPMID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 N-(2-methyl-benzyl)-phthalamic acid
  参考文献：
  名称：

  Strassmann, Chemische Berichte, 1888, vol. 21, p. 580

  摘要：

  DOI：

文献信息

• Novel intermediates useful for the preparation of antihistaminic piperidine derivatives
  申请人：Merrell Pharmaceuticals Inc.

  公开号：US20010020114A1

  公开（公告）日：2001-09-06

  The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula 1 wherein W represents —C(═O)— or —CH(OH)—; R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 and R 2 ; n is an integer of from 1 to 5; m is an integer 0 or 1; R 3 is —COOH or —COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy: and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R 1 and R 2 are ta to form a second bond between the carbon t R 1 and R 2 or where R 1 represented hydroy&ggr; integer 0.

  本发明涉及一种新型中间体和过程，其在制备某些抗组胺哌啶衍生物的过程中有用，该衍生物的化学式为1，其中W代表—C(═O)—或—CH(OH)—；R1代表氢或羟基；R2代表氢；R1和R2共同形成连接R1和R2所在碳原子之间的第二键；n为1至5的整数；m为0或1的整数；R3为—COOH或—COOalkyl，其中烷基部分具有1至6个碳原子，直链或支链，每个A均为氢或羟基；以及药学上可接受的盐和各自的光学异构体，但其中R1和R2共同形成连接R1和R2所在碳原子之间的第二键，或R1代表羟基时，m为0。
• REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1438973A1

  公开（公告）日：2004-07-21

  A pharmaceutical composition for the prophylaxis and/or treatment of diseases induced, exacerbated or reignited by stressors comprising the compound of formula (I) wherein all symbols have the same meanings as described in the specification, etc. as an active ingredient.

  一种用于预防和/或治疗由应激源诱发、加重或复燃的疾病的药物组合物，由式 (I) 化合物组成 其中所有符号的含义与说明书中所述的相同等作为活性成分。
• Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
  申请人：Seko Takuya

  公开号：US20050009812A1

  公开（公告）日：2005-01-13

  A pharmaceutical composition for the prophylaxis and/or treatment of diseases induced, exacerbated or reignited by stressors comprising the compound of formula (I) wherein all symbols have the same meanings as described in the specification, etc. as an active ingredient.
• US6552200B2
  申请人：——

  公开号：US6552200B2

  公开（公告）日：2003-04-22
• Strassmann, Chemische Berichte, 1888, vol. 21, p. 580
  作者：Strassmann

  DOI：——

  日期：——