N-<4-(3-ethyl-2,6-dioxo-3-piperidyl)phenyl>-5-dimethylamino-1-naphthalenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-<4-(3-ethyl-2,6-dioxo-3-piperidyl)phenyl>-5-dimethylamino-1-naphthalenesulfonamide
• 英文别名: 5-(dimethylamino)-N-[4-(3-ethyl-2,6-dioxopiperidin-3-yl)phenyl]naphthalene-1-sulfonamide
• 化学式: C₂₅H₂₇N₃O₄S
• 分子量: 465.573
• InChiKey: AUQRKFFVMIJQAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  氨鲁米特 、 丹酰氯 在 碳酸氢钠 作用下， 以 丙酮 为溶剂， 反应 0.5h， 以66.6%的产率得到N-<4-(3-ethyl-2,6-dioxo-3-piperidyl)phenyl>-5-dimethylamino-1-naphthalenesulfonamide
  参考文献：
  名称：

  Determination of Aminoglutethimide Enantiomers as Dansyl Derivative in Human Plasma by HPLC with Fluorescence Detection

  摘要：

  Determination of aminoglutethimide enantiomers as a dansyl derivative in plasma by HPLC has been achieved using cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD, and a mobile phase consisted of ethanol-cyclohexane-methanol (95:5:2 nu/nu/nu). The limit of detection for each enantiomer of aminoglutethimide using fluorescence detector was 20 ng ml(-1).

  DOI：

  10.1002/(sici)1521-4184(19994)332:4<145::aid-ardp145>3.0.co;2-4

文献信息

• Determination of Aminoglutethimide Enantiomers as Dansyl Derivative in Human Plasma by HPLC with Fluorescence Detection
  作者：Hassan Y. Aboul-Enein、Sumru Özkirimli、T. Idil Apak

  DOI：10.1002/(sici)1521-4184(19994)332:4<145::aid-ardp145>3.0.co;2-4

  日期：1999.4

  Determination of aminoglutethimide enantiomers as a dansyl derivative in plasma by HPLC has been achieved using cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD, and a mobile phase consisted of ethanol-cyclohexane-methanol (95:5:2 nu/nu/nu). The limit of detection for each enantiomer of aminoglutethimide using fluorescence detector was 20 ng ml(-1).