O,O-diethyl N-(4-chlorobenzenesulfonyl)-N-methylaminomethylphosphonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O,O-diethyl N-(4-chlorobenzenesulfonyl)-N-methylaminomethylphosphonate
• 英文别名: diethyl N-methyl-N-(p-chlorobenzenesulfonyl)aminomethylphosphonate；4-chloro-N-(diethoxyphosphorylmethyl)-N-methylbenzenesulfonamide
• 化学式: C₁₂H₁₉ClNO₅PS
• 分子量: 355.779
• InChiKey: AZJYWGMFYOPTOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-氯苯磺酰氯 、 diethyl N-methyl-N-(trimethylsilyl)aminomethylphosphonate 以 二氯甲烷 为溶剂， 以70%的产率得到O,O-diethyl N-(4-chlorobenzenesulfonyl)-N-methylaminomethylphosphonate
  参考文献：
  名称：

  带有 PCH2N 片段及其衍生物的新型有机磷取代的单和双（三甲基甲硅烷基）胺的合成

  摘要：

  提出了从有机磷酸的三甲基甲硅烷基酯以及 1,3,5-三烷基六氢-1,3,5-三嗪开始合成具有 PCH2N 部分的新型有机磷取代的单和双（三甲基甲硅烷基）胺的便捷方法和 N-烷氧基甲基双（三甲基甲硅烷基）胺作为氨基甲基化试剂。给出了所得化合物的某些特性。© 2010 Wiley Periodicals, Inc. 杂原子化学 21:71–77, 2010; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20580

  DOI：

  10.1002/hc.20580

文献信息

• Synthesis of new organophosphorus-substituted mono- and bis(trimethylsilyl)amines with PCH₂N fragments and their derivatives
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1002/hc.20580

  日期：——

  Convenient procedures for the synthesis of new organophosphorus-substituted mono- and bis(trimethylsilyl)amines with PCH2N moiety are proposed, starting from trimethylsilyl esters of organophosphorus acids, as well as 1,3,5-trialkylhexahydro-1,3,5-triazines and N-alkoxymethyl bis(trimethylsilyl)amines as aminomethylating reagents. Certain properties of the resulting compounds are presented. © 2010

  提出了从有机磷酸的三甲基甲硅烷基酯以及 1,3,5-三烷基六氢-1,3,5-三嗪开始合成具有 PCH2N 部分的新型有机磷取代的单和双（三甲基甲硅烷基）胺的便捷方法和 N-烷氧基甲基双（三甲基甲硅烷基）胺作为氨基甲基化试剂。给出了所得化合物的某些特性。© 2010 Wiley Periodicals, Inc. 杂原子化学 21:71–77, 2010; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.20580
• Synthesis of phosphonamides of methane- and benzenesulfonic acids bearing the P—C—N fragments
  作者：A. A. Prishchenko、M. V. Livantsov、O. P. Novikova、L. I. Livantsova、V. S. Petrosyan

  DOI：10.1007/s11172-017-1825-5

  日期：2017.5

  Preparative synthetic procedures towards new phosphorus-containing benzenesulfon-amides were elaborated. The synthesis is involved the reactions of trivalent phosphorus acids with high reactive N-methyl-N-chloromethylsulfonamide, phosphorylated methylamines bearing the NH and NSi groups, and methane-and benzenesulfonyl chlorides.

  详细阐述了新的含磷苯磺酰胺的制备合成程序。该合成涉及三价磷酸与高活性 N-甲基-N-氯甲基磺酰胺、带有 NH 和 NSi 基团的磷酸化甲胺以及甲烷和苯磺酰氯的反应。
• Prishchenko; Novikova; Livantsov, Russian Journal of General Chemistry, 1997, vol. 67, # 10, p. 1643 - 1644
  作者：Prishchenko、Novikova、Livantsov、Kustrya、Grigor'ev

  DOI：——

  日期：——
• Synthesis of new functionalized organophosphorus derivatives of methane- and 4-substituted benzenesulfonic acids with P-C-N moieties
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1002/hc.21365

  日期：2017.3

  AbstractThe convenient methods of syntheses of new organophosphorus methane‐ and 4‐substituted benzenenesulfonylamides from the trivalent organophosphorus acid esters and reactive N‐chloromethyl N‐methyl methanesulfonylamide, phosphorylated methylamines with NH‐ and NSi moieties and methane‐ and 4‐substituted benzenesulfonyl chlorides were developed. The new types of functionalized organophosphorus derivatives of methane‐ and 4‐substituted benzenesulfonic acids with P–C–N moieties were afforded in good yields.
• New functionalized organophosphorus derivatives of methane- and ethanesulfonic acids with P-C-N moieties
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1080/10426507.2016.1252369

  日期：2017.2.1

  syntheses of new organophosphorus alkanesulfonylamides from the trivalent organophosphorus acid esters and reactive N-methyl N-chloromethyl methanesulfonylamide, phosphorylated methylamines with NH- and NSi moieties, trimethylsilyl vinylsulfonate, and N,N-diethylvinylsulfonamide were developed. The new types of functionalized organophosphorus derivatives of methane- and ethanesulfonic acids with P-C-N

  图形摘要摘要开发了从三价有机磷酸酯和反应性 N-甲基 N-氯甲基甲磺酰胺、具有 NH- 和 NSi 部分的磷酸化甲胺、乙烯基磺酸三甲基甲硅烷酯和 N,N-二乙基乙烯基磺酰胺合成新型有机磷烷烃磺酰胺的便捷方法。具有 PCN 部分的新型功能化的甲磺酸和乙磺酸有机磷衍生物以良好的收率获得。