1-[(furan-3-yl)methyl]biguanide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[(furan-3-yl)methyl]biguanide
• 英文别名: 1-(Diaminomethylidene)-2-(furan-3-ylmethyl)guanidine
• 化学式: C₇H₁₁N₅O
• 分子量: 181.197
• InChiKey: AZWDIJVDYHWJRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二聚氰胺 、 3-呋喃基甲胺 在 三氟甲磺酸三甲基硅酯 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 5.0h， 生成 1-[(furan-3-yl)methyl]biguanide
  参考文献：
  名称：

  BIGUANIDE DERIVATIVES AND THEIR USE AS ANTIDIABETIC DRUGS

  摘要：

  公开号：

  EP1500656B1

文献信息

• BIGUANIDE DERIVATIVE AND THERAPEUTIC AGENT FOR DIABETES CONTAINING THE SAME
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1500656A1

  公开（公告）日：2005-01-26

  Diabetes treatments comprising, as effective ingredients, biguanide derivatives represented by the following general formula (1), or salts thereof. (wherein R1, R2 and R3 may be the same or different and each represents one selected from the group consisting of hydrogen, optionally substituted lower alkyl groups and optionally substituted lower alkylthio groups).

  包含以下通式(1)代表的双胍衍生物或其盐类作为有效成分的糖尿病治疗剂。 (其中 R1、R2 和 R3 可以相同或不同，各自代表选自氢、任选取代的低级烷基和任选取代的低级烷硫基组成的组中的一个）。
• Biguanide compositions and methods of treating metabolic disorders
  申请人：Elcelyx Therapeutics, Inc.

  公开号：US10028923B2

  公开（公告）日：2018-07-24

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含双胍类或相关杂环化合物（如二甲双胍）的组合物来治疗某些疾病（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了双胍类或相关杂环化合物组合物及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Biguanide derivative and therapeutic agent for diabetes containing the same
  申请人：Taka Naoki

  公开号：US20050124693A1

  公开（公告）日：2005-06-09

  Diabetes treatments comprising, as effective ingredients, biguanide derivatives represented by the following general formula (1), or salts thereof. (wherein R 1 , R 2 and R 3 may be the same or different and each represents one selected from the group consisting of hydrogen, optionally substituted lower alkyl groups and optionally substituted lower alkylthio groups).

  糖尿病治疗药物，其有效成分包括以下通式(1)代表的双胍衍生物或其盐类。 (其中 R 1 , R 2 和 R 3 可相同或不同，且各自代表选自氢、任选取代的低级烷基和任选取代的低级烷硫基组成的组中的一个）。
• BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS
  申请人：Anji Pharma (US) LLC

  公开号：EP2800561B1

  公开（公告）日：2020-08-19
• Biguanide Compositions and Methods of Treating Metabolic Disorders
  申请人：Baron Alain D.

  公开号：US20130095140A1

  公开（公告）日：2013-04-18

  Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.