2-(4-butoxyphenyl)acetaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-butoxyphenyl)acetaldehyde
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: BBXQQMLOLBJOKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-butoxyphenyl)acetaldehyde 、 (2R,3R,4R,5S)-3,4,5-三(苄氧基)-2-[(苄氧基)甲基]哌啶 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以86%的产率得到(2S,3R,4R,5S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-1-(4-butoxyphenethyl)piperidine
  参考文献：
  名称：

  [EN] NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS DE LA GLUCOSYLCÉRAMIDASE NON LYSOSOMALE ET LEURS UTILISATIONS

  摘要：

  这项发明提供了用于抑制葡萄糖酰胺酶的化合物，这些化合物的前药以及包括这些化合物或化合物的前药的药物组合物。

  公开号：

  WO2021224865A1
• 作为产物：
  描述：

  4-butoxy-phenethyl alcohol 在 2-碘酰基苯甲酸 作用下， 以 乙腈 为溶剂， 生成 2-(4-butoxyphenyl)acetaldehyde
  参考文献：
  名称：

  芳基叠氮化物的可见光驱动合成1,3,4-三取代的吡咯

  摘要：

  本文已经报道了通过可见光介导的光氧化还原催化的芳基叠氮化物和醛的缩合反应合成1,3,4-三取代的吡咯。该方法避免了使用化学计量的氧化剂，并以良好的产率（高达78％）和温和的条件提供了相应的含N的芳烃。通过专门的和组合的光谱/实验研究提供了机理原理。

  DOI：

  10.1021/acs.orglett.9b02731

文献信息

• Transfer sheet, method for producing transfer sheet, optical laminate, and method for producing optical laminate
  申请人：FUJIFILM Corporation

  公开号：US10688701B2

  公开（公告）日：2020-06-23

  A transfer sheet includes a cured liquid crystal composition layer, a block layer including a (meth)acrylic polymer, and a thermoplastic welded layer in this order, the thermoplastic welded layer and the block layer are in direct contact with each other, and the thermoplastic welded layer includes a thermoplastic resin and an ultraviolet curable resin.

  转印片包括固化的液晶组合物层、包括（甲基）丙烯酸聚合物的块状层和依次排列的热塑性焊接层，热塑性焊接层和块状层直接接触，热塑性焊接层包括热塑性树脂和紫外线固化树脂。
• ARYL DIHYDROPYRIDINONES AND PIPERIDINONES AS MGAT2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2785693A1

  公开（公告）日：2014-10-08
• ORGANIC DYES COMPRISING A HYDRAZONE MOIETY AND THEIR USE IN DYE-SENSITIZED SOLAR CELLS
  申请人：BASF SE

  公开号：EP2870204A2

  公开（公告）日：2015-05-13
• INFRARED LIGHT-REFLECTING FILM AND PRODUCTION METHOD THEREOF
  申请人：MAJIMA Wataru

  公开号：US20120223272A1

  公开（公告）日：2012-09-06

  A method of producing an infrared light-reflecting film includes a coating step of coating a polymerizable liquid crystal composition including a polymerizable cholesteric liquid crystal compound (A), a chiral agent having an HTP of 50 μm −1 or less (B), a monofunctional monomer (C), and an organic solvent (D) on a substrate, an alignment step of aligning the polymerizable cholesteric liquid crystal compound by heating to form a cholesteric liquid crystal phase, and an irradiation step of irradiating the polymerizable liquid crystal composition with actinic radiation to fix the cholesteric liquid crystal phase and form an infrared light-reflecting layer, wherein the amount of a residual solvent after the alignment step is controlled to 0.20 g/m 2 or more.
• ALANINE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20170037004A1

  公开（公告）日：2017-02-09

  The description relates to Inhibitors of Apoptosis Proteins (IAPs) binding compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the IAP E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.