pyrido[1,2-a]pyrimidinium perchlorate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: pyrido[1,2-a]pyrimidinium perchlorate
• 英文别名: Pyrido<1,2-a>pyrimidiniumperchlorat；Pyrido<1,2a>-pyrimidin-5-ium als Perchlorat；Pyrido[1,2-a]pyrimidin-5-ium;perchlorate
• 化学式: C₈H₇N₂*ClO₄
• 分子量: 230.608
• InChiKey: BCHWCBDTAQGGTF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.94
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  pyrido[1,2-a]pyrimidinium perchlorate 在 Rh/Al₂O₃ 、 氢气 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 3,4,6,7,8,9-hexahydro-2H-pyrido[1,2-a]pyrimidine
  参考文献：
  名称：

  Studies toward the synthesis of cinachyramine. An efficient route to 1,5-diazabicyclo[4.4.0]dec-5-enes

  摘要：

  Hydrogenation (3 atm) of readily available pyrido[1,2-a]pyrimidines 10, 14, and 17 over 5% Rh/Al2O3 forms 1,5-diazabicyclo[4.4.0]dec-5-enes 9, 15, and 18 in >95% yield, providing a general route to this little-studied class of compounds. All attempts to form the tetrahydro-1,2,4-triazine moiety of cinachyramine (1) by rearrangement of amidinium dimethylhydrazone 8 using the procedures developed by Kamatori to convert hydrazone 3a to tetrahydro-1,2,4-triazine 4a were unsuccessful. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.12.071
• 作为产物：
  描述：

  2-氨基吡啶 、 1,1,3,3-四乙氧基丙烷 在 高氯酸 作用下， 以 乙醇 为溶剂， 以86%的产率得到pyrido[1,2-a]pyrimidinium perchlorate
  参考文献：
  名称：

  Studies toward the synthesis of cinachyramine. An efficient route to 1,5-diazabicyclo[4.4.0]dec-5-enes

  摘要：

  Hydrogenation (3 atm) of readily available pyrido[1,2-a]pyrimidines 10, 14, and 17 over 5% Rh/Al2O3 forms 1,5-diazabicyclo[4.4.0]dec-5-enes 9, 15, and 18 in >95% yield, providing a general route to this little-studied class of compounds. All attempts to form the tetrahydro-1,2,4-triazine moiety of cinachyramine (1) by rearrangement of amidinium dimethylhydrazone 8 using the procedures developed by Kamatori to convert hydrazone 3a to tetrahydro-1,2,4-triazine 4a were unsuccessful. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.12.071

文献信息

• Studies toward the synthesis of cinachyramine. An efficient route to 1,5-diazabicyclo[4.4.0]dec-5-enes
  作者：Olga V. Barykina-Tassa、Barry B. Snider

  DOI：10.1016/j.tetlet.2014.12.071

  日期：2015.6

  Hydrogenation (3 atm) of readily available pyrido[1,2-a]pyrimidines 10, 14, and 17 over 5% Rh/Al2O3 forms 1,5-diazabicyclo[4.4.0]dec-5-enes 9, 15, and 18 in >95% yield, providing a general route to this little-studied class of compounds. All attempts to form the tetrahydro-1,2,4-triazine moiety of cinachyramine (1) by rearrangement of amidinium dimethylhydrazone 8 using the procedures developed by Kamatori to convert hydrazone 3a to tetrahydro-1,2,4-triazine 4a were unsuccessful. (C) 2014 Elsevier Ltd. All rights reserved.