tert-butyl 4-[(3S)-1-(4-hydroxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl 4-[(3S)-1-(4-hydroxyphenyl)-2,5-dioxopyrrolidin-3-yl]piperazine-1-carboxylate
• 化学式: C₁₉H₂₅N₃O₅
• 分子量: 375.4
• InChiKey: GTZWYUFQILWIKP-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  90.4
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• METHODS FOR ENHANCING CELLULAR CLEARANCE OF PATHOLOGICAL MOLECULES VIA ACTIVATION OF THE CELLULAR PROTEIN YKT6
  申请人：NORTHWESTERN UNIVERSITY

  公开号：US20210113552A1

  公开（公告）日：2021-04-22

  Disclosed are methods and compositions for enhancing cellular clearance of pathological molecules. Particularly disclosed are methods and compositions enhancing cellular clearance of pathological molecules via activating the cellular protein ykt6. The disclosed methods and compositions may be utilized in order to treat a subject having or at risk for developing a proteinopathy or other cellular storage disorder.