4'-methyl-biphenyl-4-sulfonic acid amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-methyl-biphenyl-4-sulfonic acid amide
• 英文别名: 4'-Methyl-biphenyl-4-sulfonsaeure-amid；4-(4-Methylphenyl)benzenesulfonamide
• 化学式: C₁₃H₁₃NO₂S
• 分子量: 247.318
• InChiKey: BGDFMHADWWOANL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 4'-methyl-biphenyl-4-sulfonic acid amide
  参考文献：
  名称：

  Kruber, Chemische Berichte, 1932, vol. 65, p. 1382,1392

  摘要：

  DOI：

文献信息

• Sulfonated N-heterocyclic carbenes for Suzuki coupling in water
  作者：Christoph Fleckenstein、Sutapa Roy、Steffen Leuthäußer、Herbert Plenio

  DOI：10.1039/b703658b

  日期：——

  Sulfonated, water-soluble imidazolium and imidazolinium salts were synthesized and the respective Pd-complexes with N,N'-bis(2,6-dialkyl-4-SO(3)(-)-phenyl)imidazol-2-ylidene and N,N'-bis(2,6-dialkyl-4-SO(3)(-)-phenyl)-4,5-dihydroimidazol-2-ylidene ligands were applied in aqueous Suzuki coupling reactions of aryl chlorides.

  合成了磺化的水溶性咪唑鎓盐和咪唑啉鎓盐，并分别与N，N'-双（2,6-二烷基-4-SO（3）（-）-苯基）咪唑-2-亚烷基和N将N′-双（2，6-二烷基-4-SO（3）（-）-苯基）-4，5-二氢咪唑-2-亚烷基配体用于芳基氯化物的水性Suzuki偶联反应。
• [EN] COMPOUNDS FOR TREATING VIRAL INFECTIONS<br/>[FR] COMPOSÉS POUR TRAITER DES INFECTIONS VIRALES
  申请人：PASTEUR INSTITUT KOREA

  公开号：WO2015158908A1

  公开（公告）日：2015-10-22

  The present invention relates to small molecule compounds and their use in the treatment of diseases, in particular viral diseases, in particular hepatitis C virus (HCV).

  本发明涉及小分子化合物及其在治疗疾病中的应用，特别是病毒性疾病，尤其是丙型肝炎病毒（HCV）。
• New cyclopentadienyl, indenyl or fluorenyl substituted phosphine compounds and their use in catalytic reactions
  申请人：Evonik Degussa GmbH

  公开号：EP1894938A1

  公开（公告）日：2008-03-05

  The invention is directed to a phosphine compound represented by general formula (1) wherein R' and R" independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R' and R" are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cps is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines.

  该发明涉及一种由通式（1）表示的膦化合物 其中 R'和R"独立地选自烷基、环烷基和2-呋喃基，或者R'和R"结合在一起与磷原子形成至少含有3个碳原子的碳-磷单环或碳-磷双环；所述烷基基团、环烷基基团和碳-磷单环未取代或取代，所述取代包括来自烷基、环烷基、芳基、烷氧基和芳氧基基团中至少一个基团的选择； Cps是部分取代或完全取代的环戊二烯-1-基团，包括导致融合环系统的取代，当环戊二烯-1-基团不是融合环系统的一部分或是茚基团的一部分时，环戊二烯-1-基团的1-位取代是强制的。还声明了这些膦化合物作为催化反应中的配体以及这些膦化合物的制备的用途。
• 9-Fluorenylphosphines for the Pd-Catalyzed Sonogashira, Suzuki, and Buchwald–Hartwig Coupling Reactions in Organic Solvents and Water
  作者：Christoph A. Fleckenstein、Herbert Plenio

  DOI：10.1002/chem.200601142

  日期：2007.3.16

  lithiation and reaction with R2PCl (R=Cy, iPr, tBu) generates 9-alkyl, 9-PR2-fluorenes which constitute electron-rich and bulky phosphine ligands. The in-situ-formed palladium-phosphine complexes ([Na2PdCl4], phosphonium salt, base, substrates) were tested in the Sonogashira, Suzuki, and Buchwald-Hartwig reactions of aryl chlorides and aryl bromides in organic solvents. The Sonogashira coupling of aryl chlorides

  芴的锂化/烷基化导致各种9-烷基芴（烷基= Me，Et，iPr，-Pr，-C18H25）> 95％的收率，对此进行锂化和与R2PC1的反应（R = Cy，iPr，tBu ）生成9-烷基，9-PR2-芴，它们构成了富电子且庞大的膦配体。在有机溶剂中的芳基氯化物和芳基溴化物的Sonogashira，Suzuki和Buchwald-Hartwig反应中测试了原位形成的钯-膦配合物（[Na2PdCl4] 、,盐，碱，底物）。在1-mol％的Pd催化剂下，在100-120摄氏度下，芳基氯化物的Sonogashira偶联可导致> 90％的收率。芳基氯的Suzuki偶联通常需要在100摄氏度的二恶烷中加入0.05摩尔％的Pd催化剂，以定量形成产物。为了在水中进行“绿色”交叉偶联反应，使9-乙基芴基二环己基膦在硫酸中反应，生成相应的2-磺化phospho盐。通过使用这种水溶性催化剂进行的活化芳基氯的Suzuki偶联仅需要0
• CYCLOPENTADIENYL, INDENYL OR FLUORENYL SUBSTITUTED PHOSPHINE COMPOUNDS AND THEIR USE IN CATALYTIC REACTIONS
  申请人：Plenio Herbert

  公开号：US20090253907A1

  公开（公告）日：2009-10-08

  A phosphine compound represented by general formula (1) wherein R′ and R″ independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R′ and R″ are joined together to form with the phosphorous atom a carbon-phosphorous monocycle including at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cp s is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. These phosphines can be used as ligands in catalytic reactions.

  一种磷化合物，其通式表示为（1），其中R'和R''独立地选择烷基，环烷基和2-呋喃基基团，或者R'和R''与磷原子结合形成至少包括3个碳原子的碳-磷单环或碳-磷双环；烷基基团，环烷基基团和碳-磷单环未经取代或被至少一种从烷基，环烷基，芳基，烷氧基和芳氧基基团组成的基团取代；Cps是部分取代或完全取代的环戊二烯-1-基基团，包括导致融合环系统的取代，当环戊二烯-1-基基团不是融合环系统的一部分或是一个茚基基团的一部分时，必须在环戊二烯-1-基基团的1位进行取代。这些磷化物可以用作催化反应中的配体。