nebrosamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: nebrosamine
• 英文别名: (2R,4S,5R)-2,6-diamino-4,5-dihydroxyhexanal
• 化学式: C₆H₁₄N₂O₃
• 分子量: 162.189
• InChiKey: BHSBUACOLPRNSU-NGJCXOISSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  尼拉霉素 在 氘代硫酸 作用下， 以 重水 为溶剂， 反应 113.0h， 生成 3-氨基-3-脱氧-D-葡萄糖 、 nebrosamine
  参考文献：
  名称：

  核糖体糖的核磁共振管降解方法

  摘要：

  天然糖苷的糖亚基可方便地通过酸水解和1 H NMR光谱测定，而无需分离或衍生。端基异构体信号的化学位移，偶联常数和积分比可以鉴定每种单糖，并可以定量其与其他单糖的摩尔比。报道了28种单糖和3种二糖的异头异构体信号的NMR数据。类黄酮苷柚皮苷柚皮苷（1），氨基糖苷类抗生素卡那霉素（2）和妥布霉素（3）以及皂苷洋地黄皂苷（4）证明了该方法的应用。

  DOI：

  10.1021/acs.jnatprod.6b00180

文献信息

• METHODS FOR PRODUCING AMINO-SUBSTITUTED GLYCOLIPID COMPOUNDS
  申请人：Sparsø Flemming Vang

  公开号：US20120315373A1

  公开（公告）日：2012-12-13

  A method of preparing a compound of formula (I): wherein: a first group selected from R 1 , R 2 and R 3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R 1 , R 2 and R 3 is a saturated or unsaturated acyi group having 3 to 40 carbon atoms; and a third group selected from R 1 , R 2 and R 3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described. Novel compounds, as well as In situ methods for producing the compounds, and their use as emulsifiers, surfactants and antimicrobial agents, particularly in foodstuffs and detergent compositions, are also described.
• US9045514B2
  申请人：——

  公开号：US9045514B2

  公开（公告）日：2015-06-02
• NMR Tube Degradation Method for Sugar Analysis of Glycosides
  作者：José-Luis Giner、Ju Feng、David J. Kiemle

  DOI：10.1021/acs.jnatprod.6b00180

  日期：2016.9.23

  The sugar subunits of natural glycosides can be conveniently determined by acid hydrolysis and 1H NMR spectroscopy without isolation or derivatization. The chemical shifts, coupling constants, and integral ratios of the anomeric signals allow each monosaccharide to be identified and its molar ratio to other monosaccharides to be quantified. The NMR data for the anomeric signals of 28 monosaccharides

  天然糖苷的糖亚基可方便地通过酸水解和1 H NMR光谱测定，而无需分离或衍生。端基异构体信号的化学位移，偶联常数和积分比可以鉴定每种单糖，并可以定量其与其他单糖的摩尔比。报道了28种单糖和3种二糖的异头异构体信号的NMR数据。类黄酮苷柚皮苷柚皮苷（1），氨基糖苷类抗生素卡那霉素（2）和妥布霉素（3）以及皂苷洋地黄皂苷（4）证明了该方法的应用。