丙烯酰芬太尼 | 82003-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 丙烯酰芬太尼
• 英文名称: acrylfentanyl
• 英文别名: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]prop-2-enamide
• CAS: 82003-75-6
• 化学式: C₂₂H₂₆N₂O
• 分子量: 334.461
• InChiKey: RFQNLMWUIJJEQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  N-苯基-1-(2-苯乙基)-4-哌啶胺	(1-Phenethyl-piperidin-4-yl)-phenyl-amine	21409-26-7	C19H24N2	280.413

反应信息

• 作为产物：
  描述：

  N-苯基-1-(2-苯乙基)-4-哌啶胺 、 3-氯丙酰氯 在 TEA 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以67%的产率得到丙烯酰芬太尼
  参考文献：
  名称：

  Essawi, Pharmazie, 1999, vol. 54, # 4, p. 307 - 308

  摘要：

  DOI：

文献信息

• NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
  申请人：Adapt Pharma Limited

  公开号：US20170071851A1

  公开（公告）日：2017-03-16

  Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.
• Colorimetric Detection of Organic Amines Using Metal-Organic Frameworks
  申请人：The Johns Hopkins University

  公开号：US20200249172A1

  公开（公告）日：2020-08-06

  Provided is an article for detecting organic amines, wherein the article includes a solid support impregnated with an indicator reagent comprising a metal-organic framework structure. Also provided is a method of detecting organic amines, wherein the method includes the step of exposing an article comprising a solid support impregnated with an indicator reagent to a medium including an organic amine to produce a color change, wherein the indicator reagent includes a metal-organic framework structure.
• FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF
  申请人：Veriteque USA, Inc.

  公开号：US20220390439A1

  公开（公告）日：2022-12-08

  A portable detection kit for identifying the presence of narcotic compounds (NCs) includes at least one chemical dye, a catalytic reagent, at least one solvent, and a least one surfactant. The at least one dry chemical dye is configured to undergo physic-chemical interaction with at least one predetermined NC to produce a color visible change. The at least one predetermined NC is selected from the group consisting of fentanyl analogues (FAs) and narcotics containing nitrogen heterocyclic moiety.
• Essawi, Pharmazie, 1999, vol. 54, # 4, p. 307 - 308
  作者：Essawi

  DOI：——

  日期：——