N-{3-[3-(3-imidazol-1-yl-propyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-ylmethyl]-benzyl}-methanesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: N-{3-[3-(3-imidazol-1-yl-propyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-ylmethyl]-benzyl}-methanesulfonamide
• 英文别名: N-(3-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)benzyl)methanesulfonamide；N-[[3-[[3-(3-imidazol-1-ylpropyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxoimidazolidin-1-yl]methyl]phenyl]methyl]methanesulfonamide
• 化学式: C₂₉H₃₁N₅O₄S
• 分子量: 545.662
• InChiKey: BIHDOYKIKJUQTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(3-羟基丙基)-1H-咪唑 在 sodium hydride 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 生成 N-{3-[3-(3-imidazol-1-yl-propyl)-5-methyl-5-naphthalen-1-yl-2,4-dioxo-imidazolidin-1-ylmethyl]-benzyl}-methanesulfonamide
  参考文献：
  名称：

  Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase

  摘要：

  1, 3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.074

文献信息

• HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE
  申请人：LG CHEMICAL LIMITED

  公开号：EP1000036A1

  公开（公告）日：2000-05-17
• US6384061B1
  申请人：——

  公开号：US6384061B1

  公开（公告）日：2002-05-07
• [EN] HYDANTOIN DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE<br/>[FR] DERIVES D'HYDANTOINE DOTES D'UNE ACTIVITE INHIBITRICE VIS A VIS DE LA FARNESYLE TRANSFERASE
  申请人：LG CHEMICAL LTD.

  公开号：WO1999005117A1

  公开（公告）日：1999-02-04

  (EN) The present invention relates to novel hydantoin derivatives represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are defined as described below. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.(FR) La présente invention se rapporte à de nouveaux dérivés d'hydantoïne représentés par la formule (I) ou à des sels pharmaceutiquement acceptables de ces composés qui sont dotés d'une activité inhibitrice vis à vis de la farnésyle transférase et peuvent par conséquent être utilisés en tant qu'agents anticancéreux. Dans la formule (I), R1, R2, R3 et R4 sont définis dans le descriptif de l'invention. La présente invention se rapporte également à un processus de préparation du composé représenté par la formule (I), et à une composition anticancéreuse contenant ce composé en tant que principe actif.
• Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase
  作者：Jinho Lee、Jonghyun Kim、Jong Sung Koh、Hyun-Ho Chung、Kyoung-Hee Kim

  DOI：10.1016/j.bmcl.2005.12.074

  日期：2006.4

  1, 3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps. (C) 2006 Elsevier Ltd. All rights reserved.