4-(3-bromo-4-fluorophenyl)-3-cyano-2-methyl-5-methoxy-1,4-dihydro[1,6]naphthyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(3-bromo-4-fluorophenyl)-3-cyano-2-methyl-5-methoxy-1,4-dihydro[1,6]naphthyridine
• 英文别名: 4-(3-Bromo-4-fluorophenyl)-5-methoxy-2-methyl-1,4-dihydro-1,6-naphthyridine-3-carbonitrile
• 化学式: C₁₇H₁₃BrFN₃O
• 分子量: 374.212
• InChiKey: BIOWQAMZLUJQKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  57.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(3-bromo-4-fluorophenyl)-3-cyano-2-methyl-4,6-dihydro[1,6]naphthyridin-5(1H)-one 、 trimethoxonium tetrafluoroborate 在 sodium carbonate 作用下， 以 二氯甲烷 为溶剂， 以24%的产率得到4-(3-bromo-4-fluorophenyl)-3-cyano-2-methyl-5-methoxy-1,4-dihydro[1,6]naphthyridine
  参考文献：
  名称：

  Dihydronaphthyridine potassium channel openers

  摘要：

  化合物I1的公式在治疗由钾通道开放剂预防或改善的疾病中很有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。

  公开号：

  US20020099070A1

文献信息

• DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS
  申请人：ABBOTT LABORATORIES

  公开号：EP1307453A2

  公开（公告）日：2003-05-07
• [EN] DIHYDRONAPHTHYRIDINE POTASSIUM CHANNEL OPENERS<br/>[FR] COMPOSITIONS UTILES POUR OUVRIR DES CANAUX POTASSIUM AU DIHYDRONAPHTHYRIDINE
  申请人：ABBOTT LAB

  公开号：WO2002010164A2

  公开（公告）日：2002-02-07

  Compounds of formula (I) wherein in R2 and R3, together with the carbon atoms to which each is attached, are a ring selected from the group consisting of (II, III, IV, V) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• Dihydronaphthyridine potassium channel openers
  申请人：——

  公开号：US20020099070A1

  公开（公告）日：2002-07-25

  Compounds of formula I 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  化合物I1的公式在治疗由钾通道开放剂预防或改善的疾病中很有用。还公开了钾通道开放组合物和在哺乳动物中开放钾通道的方法。