dansyl glycinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dansyl glycinamide
• 英文别名: [[5-(dimethylamino)-1-naphthalenyl]sulfonyl]glycinamide；2-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]acetamide
• 化学式: C₁₄H₁₇N₃O₃S
• 分子量: 307.373
• InChiKey: BJMRFOZZBBPXTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  氯甲酸甲酯 、 dansyl glycinamide 在 NaH 作用下， 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 、 N,N-二甲基甲酰胺 为溶剂， 以52.6%的产率得到1-[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-2,4-imidazolidinedione
  参考文献：
  名称：

  Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful

  摘要：

  本文披露了萘磺酰基咪唑二酮及其硫代类似物以及它们的制备方法。这些化合物是新型的醛糖还原酶抑制剂，可用于治疗或预防糖尿病并发症。

  公开号：

  US04743611A1
• 作为产物：
  描述：

  丹酰氯 、 甘氨酰胺 在 碳酸氢钠 作用下， 以 丙酮 为溶剂， 反应 1.0h， 生成 dansyl glycinamide
  参考文献：
  名称：

  Quantitation of 3-Aminopropionamide in PotatoesA Minor but Potent Precursor in Acrylamide Formation

  摘要：

  3-Aminopropionamide (3-APA) has recently been suggested as a transient intermediate in acrylamide (AA) formation during thermal degradation of asparagine initiated by reducing carbohydrates or aldehydes, respectively. 3-APA may also be formed in foods by an enzymatic decarboxylation of asparagine. Using a newly developed method to quantify 3-APA based on liquid chromatography/ tandem mass spectrometry, it could be shown that the biogenic amine was present in several potato cultivars in different amounts. Further experiments indicated that 3-APA is formed during storage of intact potatoes (20 or 35 degreesC) or after crushing of the cells. The heating of 3-APA under aqueous or low water conditions at temperatures between 100 and 180 degreesC in model systems always generated more AA than in the same reaction of asparagine, thereby pointing to 3-APA as a very effective precursor of AA. While the highest yields measured were about 28 mol % in the presence of carbohydrates (170 degreesC; aqueous buffer), in the absence of carbohydrates, 3-APA was even converted by about 63 mol % into AA upon heating at 170 degreesC under aqueous conditions. Propanoic acid amides bearing an amino or hydroxy group in the alpha-position, such as 2-hydroxypropionamide and L-alaninamide, were ineffective in AA generation indicating that elimination occurs only from the beta-position.

  DOI：

  10.1021/jf049581s

文献信息

• PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS
  申请人：Ugisense AG

  公开号：US20170166900A1

  公开（公告）日：2017-06-15

  The invention relates to new peptide nucleic acid monomers and peptide nucleic acid oligomers comprising a dialkylamine side chain substituted with phosphonic acid ester group(s) or phosphonic acid group(s), and to the uses thereof.

  本发明涉及新的肽核酸单体和肽核酸寡聚物，包括具有磷酸酯基团或磷酸基团取代的二烷基胺侧链，以及其用途。
• Naphthalenylsulfonylimidazolidinediones and their thioxo analogs
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0251784A2

  公开（公告）日：1988-01-07

  The invention comprises naphthalenylsulfonylimidazolidinediones of formula (I) wherein R⁴, R⁵, R⁶ and R⁷ are hydrogen, halogen, trifluoromethyl, methoxy or dimethylamino and X is oxygen or sulfur and the pharmaceutically acceptable salts thereof, and methods for their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications. Pharmaceutical compositions containing the compounds and methods for manufacturing same are also included in the invention.

  本发明包括式 (I) 的萘基磺酰亚胺唑烷二酮，其中 R⁴、R⁵、R⁶ 和 R⁷ 是氢、卤素、三氟甲基、甲氧基或二甲基氨基，X 是氧或硫及其药学上可接受的盐，以及它们的制备方法。 这些化合物是新型醛糖还原酶抑制剂，可用于治疗或预防糖尿病并发症。 本发明还包括含有这些化合物的药物组合物及其生产方法。
• US4743611A
  申请人：——

  公开号：US4743611A

  公开（公告）日：1988-05-10