(3S,5R)-5-(2,5-difluorophenyl)pyrrolidin-3-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S,5R)-5-(2,5-difluorophenyl)pyrrolidin-3-ol
• 化学式: C₁₀H₁₁F₂NO
• 分子量: 199.2
• InChiKey: NMLNIXYQBXUCPH-OIBJUYFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SIX-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND AND USES THEREOF SERVING AS PROTEIN RECEPTOR KINASE INHIBITOR
  申请人：SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD.

  公开号：US20220017512A1

  公开（公告）日：2022-01-20

  Provided are a preparation and applications of a six-membered fused with six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases.