dichlorobenzyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichlorobenzyl ether
• 英文别名: 1,2-Dichloro-3-[(2,3-dichlorophenyl)methoxymethyl]benzene
• 化学式: C₁₄H₁₀Cl₄O
• 分子量: 336.045
• InChiKey: BKGPDPOATDMPJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,6-二氯苄基溴 、 Methyl(E)-3-(2-((E)-3-(2-hydroxy-3-methylphenyl)-2-propenyl)phenyl)-2-propenoate 在 NaH 作用下， 生成 dichlorobenzyl ether
  参考文献：
  名称：

  Prostaglandin receptor ligands

  摘要：

  本发明揭示了用于治疗前列腺素介导疾病的化合物和方法，以及某些制药组合物。这些化合物由式II表示：Ar1—W—Ar2—X—Q。该发明的化合物在结构上与非甾体类抗炎药和阿片类药物不同，是E型前列腺素的疼痛和炎症作用的拮抗剂。

  公开号：

  US06211197B1

文献信息

• Piperidone derivatives and medical uses thereof
  申请人：Heinrich-Pette-Institut

  公开号：EP2036556A1

  公开（公告）日：2009-03-18

  The present invention relates to compositions comprising 4-Oxo-piperidine-carboxylates and derivatives thereof, for example derivatives substituted with phenyl, nitrophenyl or benzyl groups. It also teaches the medical use of these and related compounds for treatment of retroviral diseases, in particular, HIV and HTLV, proliferative diseases, in particular CML and Trypanosomiasis.

  本发明涉及包含4-氧代哌啶羧酸酯及其衍生物的组合物，例如用苯基、硝基苯基或苄基取代的衍生物。它还教导了这些相关化合物的医药用途，用于治疗逆转录病毒性疾病，特别是HIV和HTLV，增殖性疾病，特别是慢性髓细胞白血病和锥虫病。
• Nuclear receptor binding agents
  申请人：Dalton T. James

  公开号：US20070265296A1

  公开（公告）日：2007-11-15

  The present invention relates to a novel class of selective estrogen receptor modulators (SERMs). The SERM compounds are applicable for use in the prevention and/or treatment of a variety of diseases and conditions including prevention and treatment of cancers such as prostate and breast cancer, osteoporosis, hormone-related diseases, hot flashes or vasomotor symptoms, neurological disorders, cardiovascular disease and obesity.

  本发明涉及一种新型选择性雌激素受体调节剂（SERMs）类。该SERM化合物适用于预防和/或治疗各种疾病和情况，包括预防和治疗癌症，如前列腺癌和乳腺癌，骨质疏松症，激素相关疾病，潮热或血管运动症状，神经系统疾病，心血管疾病和肥胖症。
• Preparation of dichlorobenzyl alcohol
  申请人：The Boots Company PLC

  公开号：EP0047622A1

  公开（公告）日：1982-03-17

  2,4-Dichlorobenzyl alcohol is obtained in high purity and in high yield by reacting 2,4-dichlorobenzyl chloride in a two stage reaction with a water soluble salt of an organic acid in the presence of a phase transfer catalyst to give the 2,4-di- chlorbenzyl ester of the organic acid which is subsequently hydrolysed with a strong base.

  在相转移催化剂的作用下，2,4-二氯苄基氯与有机酸的水溶性盐进行两阶段反应，生成有机酸的 2,4-二氯苄基酯，然后用强碱进行水解，即可获得高纯度和高产率的 2,4-二氯苄醇。
• Immunological composition and method for hepatitis B virus
  申请人：Baylor College of Medicine

  公开号：EP0082789A2

  公开（公告）日：1983-06-29

  A composition for eliciting production of antibody to hepatitis B surface antigen and method of neutralizing the infectivity of hepatitis type B virus. A cyclic polypeptide is prepared having a disulfide bond in a hydrophilic region, namely residues 117-137 or 122-137 and an amino acid sequence unique from that associated with the native 25,000 molecular weight polypeptide derived from hepatitis B surface antigen.

  一种诱导产生乙型肝炎表面抗原抗体的组合物和中和乙型肝炎病毒传染性的方法。 制备的环状多肽在亲水区（即残基 117-137 或 122-137）具有二硫键，其氨基酸序列与源自乙型肝炎表面抗原的原生 25,000 分子量多肽的氨基酸序列不同。
• Compositions and methods for treating viral infections
  申请人：Probe International Inc.

  公开号：US20020086034A1

  公开（公告）日：2002-07-04

  Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential events in the life cycle of the virus. The antibodies recognize viral epitopes which fail to elicit an immune response in man when encountered through infection or naturally through the environment. In a preferred embodiment, the invention provides compositions and methods useful in the treatment and diagnosis of human immunodeficiency virus (HIV) infections.

  用于治疗、诊断和预防病毒的方法和组合物包括给病人注射抗体，这种抗体与病毒蛋白质的区域发生反应，从而中和病毒的感染性，并使病毒生命周期中功能必需的事件失活。这种抗体能识别病毒表位，当人类通过感染或自然环境遇到这些表位时，这些表位不能引起免疫反应。在一个优选的实施方案中，本发明提供了用于治疗和诊断人类免疫缺陷病毒（HIV）感染的组合物和方法。