3-(4-chloro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid (2-piperidine-1-yl-ethyl)-amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(4-chloro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid (2-piperidine-1-yl-ethyl)-amide
• 英文别名: 3-(4-chloro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylic acid (2-piperidin-1-yl-ethyl)amide；3-(4-chlorobenzyl)-2,4-dioxo-N-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide；3-[(4-chlorophenyl)methyl]-2,4-dioxo-N-(2-piperidin-1-ylethyl)-1H-quinazoline-7-carboxamide
• 化学式: C₂₃H₂₅ClN₄O₃
• 分子量: 440.929
• InChiKey: BKSKSEWIBBBRSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-氨乙基)哌啶 、 3-(4-chlorobenzyl)-2,4-dioxoquinazoline-7-carboxylic acid 生成 3-(4-chloro-benzyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid (2-piperidine-1-yl-ethyl)-amide
  参考文献：
  名称：

  PHARMACEUTICAL COMPOSITIONS CONTAINING QUINAZOLINE DERIVATIVES FOR TREATING AS SEROTONIN RECEPTOR ANTAGONIST

  摘要：

  本发明涉及一种制药组合物，其包含一种或多种喹唑啉化合物作为活性成分，具有拮抗血清素5-HT3A的活性，并且对于预防和治疗中枢神经系统（CNS）疾病，包括呕吐、恶心、酗酒、药物滥用、抑郁症、强迫神经症、焦虑、癫痫、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、精神病、精神分裂症、自杀倾向、睡眠障碍、食欲障碍和偏头痛方面具有疗效。

  公开号：

  US20090054433A1

文献信息

• PHARMACEUTICAL COMPOSITIONS CONTAINING QUINAZOLINE DERIVATIVES FOR TREATING AS SEROTONIN RECEPTOR ANTAGONIST
  申请人：NAM Ghil Soo

  公开号：US20090054433A1

  公开（公告）日：2009-02-26

  The present invention relates to a pharmaceutical composition containing one or more quinazoline compounds as an active ingredient, which has antagonistic activity against serotonin 5-HT 3 A and is effective for the prevention and treatment of central nervous system (CNS) diseases, including emesis, nausea, alcoholism, drug abuse, depression, compulsive neurosis, anxiety, seizure, Alzheimer's disease, Parkinson's disease, Huntington's chorea, psychosis, schizophrenia, suicidal tendency, sleep disorder, appetite disorder and migraine.

  本发明涉及一种药物组合物，其包含一种或多种喹唑啉化合物作为活性成分，具有对5-HT3A血清素拮抗活性，并且对预防和治疗中枢神经系统（CNS）疾病有效，包括呕吐、恶心、酗酒、药物滥用、抑郁症、强迫神经症、焦虑、癫痫、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、精神病、精神分裂症、自杀倾向、睡眠障碍、食欲障碍和偏头痛。
• US8748422B2
  申请人：——

  公开号：US8748422B2

  公开（公告）日：2014-06-10
• Pharmaceutical compositions containing quinazoline derivatives for treating as serotonin receptor antagonist
  申请人：Nam Ghil Soo

  公开号：US08748422B2

  公开（公告）日：2014-06-10

  The present invention relates to a pharmaceutical composition containing one or more quinazoline compounds as an active ingredient, which has antagonistic activity against serotonin 5-HT3A and is effective for the prevention and treatment of central nervous system (CNS) diseases, including emesis, nausea, alcoholism, drug abuse, depression, compulsive neurosis, anxiety, seizure, Alzheimer's disease, Parkinson's disease, Huntington's chorea, psychosis, schizophrenia, suicidal tendency, sleep disorder, appetite disorder and migraine.

  本发明涉及一种药物组合物，包含一种或多种喹唑啉类化合物作为活性成分，具有对5-HT3A血清素的拮抗活性，并对中枢神经系统（CNS）疾病的预防和治疗有效，包括呕吐、恶心、酗酒、药物滥用、抑郁症、强迫神经症、焦虑症、癫痫、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、精神病、精神分裂症、自杀倾向、睡眠障碍、食欲障碍和偏头痛。