Fmoc-Gly(-N(Boc)-CH2-CO2tBu)-OH

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Fmoc-Gly(-N(Boc)-CH2-CO2tBu)-OH
• 英文别名: 2-[N-(tert-butoxycarbonyl)-N-(tert-butoxycarbonylmethyl)]amino 2-N-fluorenylmethoxycarbonylamino acetic acid；2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[(2-methylpropan-2-yl)oxycarbonyl-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]acetic acid
• 化学式: C₂₈H₃₄N₂O₈
• 分子量: 526.587
• InChiKey: BNWDYGCDQVKSTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  芴甲氧羰酰胺 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 生成 Fmoc-Gly(-N(Boc)-CH2-CO2tBu)-OH
  参考文献：
  名称：

  Toward Synthesis of α-Alkyl Amino Glycines (A3G), New Amino Acid Surrogates

  摘要：

  A general method giving access to protected alpha-alkyl amino glycines (A3G) 4 from the previously described precursor alpha-isopropylthioglycine I is described. In the presence of N-bromosuccinimide, displacement of the thiol by a large variety of amines afforded the corresponding racemic amino acid mimics. The efficiency of the reaction was strongly dependent on the protective groups of the nucleophile used in the condensation.

  DOI：

  10.1021/jo020154s

文献信息

• Toward Synthesis of α-Alkyl Amino Glycines (A3G), New Amino Acid Surrogates
  作者：Loïc Yaouancq、Loïc René、Marie-Elise Tran Huu Dau、Bernard Badet

  DOI：10.1021/jo020154s

  日期：2002.7.1

  A general method giving access to protected alpha-alkyl amino glycines (A3G) 4 from the previously described precursor alpha-isopropylthioglycine I is described. In the presence of N-bromosuccinimide, displacement of the thiol by a large variety of amines afforded the corresponding racemic amino acid mimics. The efficiency of the reaction was strongly dependent on the protective groups of the nucleophile used in the condensation.