4-(4-(dimethylamino)phenyl)-6-phenylpyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(4-(dimethylamino)phenyl)-6-phenylpyrimidin-2-amine
• 英文别名: 4-[4-(dimethylamino)phenyl]-6-phenylpyrimidin-2-amine
• 化学式: C₁₈H₁₈N₄
• 分子量: 290.368
• InChiKey: VIFVVHRUEGGGFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.46
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.04
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  胍 、 4-dimethylamino-chalcone 在 titanium(IV) oxide 作用下， 以 乙醇 为溶剂， 反应 0.33h， 以62%的产率得到4-(4-(dimethylamino)phenyl)-6-phenylpyrimidin-2-amine
  参考文献：
  名称：

  Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines using nanoTiO2

  摘要：

  Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines was carried out by using nano TiO2. The method follows a green route by avoiding the use of toxic organic solvents and tedious experimental conditions. Compared with conventional methods the present strategy offers excellent yield under UV irradiation for a period of 20 min in ethanolic medium. Only a small quantity of nanocatalyst (1 mol%) is sufficient to achieve the completion of the reaction. The nanocatalyst can be reused up to four reaction cycles without much loss in the activity.

  DOI：

  10.1016/j.jphotochem.2020.112648

文献信息

• Synthesis, Crystal Structure, and Photophysical Properties of 4-(4-(Dimethylamino)phenyl)-6-phenylpyrimidin-2-amine
  作者：Marco Mellado、Rafaela Sariego-Kluge、Franco Valdés-Navarro、Rodrigo Sánchez-González、Mauricio Fuentealba、Manuel A. Bravo、Luis F. Aguilar

  DOI：10.1016/j.molstruc.2020.129340

  日期：2021.2

  Abstract The pyrimidine core is present in a wide variety of compounds that show interesting fluorescent properties and have been used as pigments and dyes. In this research, we synthesized 4-(4-(dimethylamino)phenyl)-6-phenylpyrimidin-2-amine (compound 9) from chalcone (8) with 45% yield. We obtained monocrystals of 9 by slow evaporation of dichloromethane as a solvent. Additionally, we measured the

  摘要 嘧啶核存在于多种化合物中，这些化合物显示出有趣的荧光特性，并已被用作颜料和染料。在本研究中，我们从查耳酮 (8) 中合成了 4-(4-(二甲氨基)苯基)-6-苯基嘧啶-2-胺（化合物 9），产率为 45%。我们通过缓慢蒸发作为溶剂的二氯甲烷获得 9 的单晶。此外，我们测量了化合物9的光物理性质，其吸收波长（λabs）、摩尔吸收系数（e）、激发波长（λexc）和发射波长（λem）以及斯托克斯位移（Δλ）随着增加而增加。溶剂极性。这些性质都与溶剂稳定激发态有关。另一方面，
• Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines using nanoTiO2
  作者：Aparna E.P.、Divya Mathew、Ashly Thomas、Rakesh N、Devaky K.S.

  DOI：10.1016/j.jphotochem.2020.112648

  日期：2020.8

  Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines was carried out by using nano TiO2. The method follows a green route by avoiding the use of toxic organic solvents and tedious experimental conditions. Compared with conventional methods the present strategy offers excellent yield under UV irradiation for a period of 20 min in ethanolic medium. Only a small quantity of nanocatalyst (1 mol%) is sufficient to achieve the completion of the reaction. The nanocatalyst can be reused up to four reaction cycles without much loss in the activity.