previtamin D₃

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: previtamin D₃
• 英文别名: (1S)-3-[2-[(1R,3aR,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-4-methylcyclohex-3-en-1-ol
• 化学式: C₂₇H₄₄O
• 分子量: 384.646
• InChiKey: YUGCAAVRZWBXEQ-RWDMXNMGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  7-去氢胆固醇 生成 previtamin D₃ 、 维生素 D3
  参考文献：
  名称：

  Photochemical transformations of 7-dehydrocholesterol

  摘要：

  Photochemical transformations of 7-dehydrocholesterol were performed with a two-lamp experimental circulation installation equipped with a ferrioxalate actinometer and were monitored by UV spectroscopy and high-performance liquid chromatography. The quantum yields of the overall conversion of 7-dehydrocholesterol at wavelengths of 254, 313, and 365 nm were determined.

  DOI：

  10.1134/s1070427209030306

文献信息

• Continuous-flow synthesis of vitamin D3
  作者：Shinichiro Fuse、Nobutake Tanabe、Masahito Yoshida、Hayato Yoshida、Takayuki Doi、Takashi Takahashi

  DOI：10.1039/c0cc02239j

  日期：——

  A highly efficient, two-stage, continuous-flow synthesis of vitamin D3 from provitamin D3 was achieved. The developed method afforded the desired product in high yield (HPLC-UV: 60%, isolated: 32%) and required neither intermediate purification nor high-dilution conditions.

  实现了从维生素 D3 到维生素 D3 的高效、两阶段、连续流合成。所开发的方法能以高产率（HPLC-UV：60%，分离：32%）获得所需的产品，并且既不需要中间纯化，也不需要高稀释条件。
• Photochemical transformations of 7-dehydrocholesterol
  作者：Z. L. Grigoryan、A. I. Martiryan、L. A. Nersesyan、Sh. A. Markaryan

  DOI：10.1134/s1070427209030306

  日期：2009.3

  Photochemical transformations of 7-dehydrocholesterol were performed with a two-lamp experimental circulation installation equipped with a ferrioxalate actinometer and were monitored by UV spectroscopy and high-performance liquid chromatography. The quantum yields of the overall conversion of 7-dehydrocholesterol at wavelengths of 254, 313, and 365 nm were determined.