(1S,2R)-N-[3,5-di[3,5-di[3,5-di(2-methoxyethoxy)]benzyloxy]benzyloxy]benzyl-2-amino-1-phenyl-1-propanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2R)-N-[3,5-di[3,5-di[3,5-di(2-methoxyethoxy)]benzyloxy]benzyloxy]benzyl-2-amino-1-phenyl-1-propanol
• 英文别名: (1S,2R)-2-[[3,5-bis[[3,5-bis[[3,5-bis(2-methoxyethoxy)phenyl]methoxy]phenyl]methoxy]phenyl]methylamino]-1-phenylpropan-1-ol
• 化学式: C₈₂H₁₀₃NO₂₃
• 分子量: 1470.71
• InChiKey: NLKJEYRRQKRFMV-KVYRPLCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  106
• 可旋转键数：
  55
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  235
• 氢给体数：
  2
• 氢受体数：
  24

反应信息

• 作为产物：
  描述：

  左旋去甲麻黄碱 、 1,3-Bis[[3,5-bis[[3,5-bis(2-methoxyethoxy)phenyl]methoxy]phenyl]methoxy]-5-(bromomethyl)benzene 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以68%的产率得到(1S,2R)-N-[3,5-di[3,5-di[3,5-di(2-methoxyethoxy)]benzyloxy]benzyloxy]benzyl-2-amino-1-phenyl-1-propanol
  参考文献：
  名称：

  Dendritic catalysts for asymmetric transfer hydrogenation based (1S,2R)-norephedrine derived ligands

  摘要：

  Two series of novel dendritic ligands based on (1S,2R)-norephedrine have been designed and synthesized, and incorporated into Ru(II) complexes as catalysts for asymmetric transfer hydrogenation. Some dendritic catalysts demonstrated dendritic acceleration effects as well as high catalytic activity and good enantioselectivity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00522-6

文献信息

• Dendritic catalysts for asymmetric transfer hydrogenation based (1S,2R)-norephedrine derived ligands
  作者：Pei Nian Liu、Ying Chun Chen、Xue Qiang Li、Yong Qiang Tu、Jin Gen Deng

  DOI：10.1016/s0957-4166(03)00522-6

  日期：2003.8

  Two series of novel dendritic ligands based on (1S,2R)-norephedrine have been designed and synthesized, and incorporated into Ru(II) complexes as catalysts for asymmetric transfer hydrogenation. Some dendritic catalysts demonstrated dendritic acceleration effects as well as high catalytic activity and good enantioselectivity. (C) 2003 Elsevier Ltd. All rights reserved.