This work combined three classes of compounds in the same molecule "amino triazole-glycoside" and developed a convenient method for the synthesis of this type of compound via a one-pot two step reaction. Alkylation of amine derivatives with propargyl bromide to give propargylamine was performed in the first step subsequently followed by a 'click' reaction with various β-azido-glycosides in the presence
这项工作在同一分子“
氨基三唑-糖苷”中结合了三类化合物,并开发了一种通过一锅两步反应合成此类化合物的简便方法。在第一步中,将胺衍
生物与炔丙基
溴烷基化以得到
炔丙基胺,随后在
水溶液中存在CuI的情况下,与各种β-
叠氮基糖苷进行“点击”反应,以提供β-
氨基三唑糖苷。使用该一锅法,以中等至良好的产率获得了32个糖苷实例。