benzhydrylamine hydrophosphorous acid salt

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzhydrylamine hydrophosphorous acid salt
• 英文别名: diphenylmethylamine hypophosphite；Diphenylmethanamine;phosphonous acid
• 化学式: C₁₃H₁₃N*H₃O₂P
• 分子量: 249.249
• InChiKey: RHFJBEMFZQFYIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.21
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-吲哚基)-2-氧代丙酸 、 benzhydrylamine hydrophosphorous acid salt 以 1,4-二氧六环 为溶剂， 以22%的产率得到[1-(Benzhydryl-amino)-2-(1H-indol-3-yl)-ethyl]-phosphinic acid
  参考文献：
  名称：

  Baylis, E. Keith; Campbell, Colin D.; Dingwall, John G., Journal of the Chemical Society. Perkin transactions I, 1984, p. 2845 - 2853

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯甲胺 生成 benzhydrylamine hydrophosphorous acid salt
  参考文献：
  名称：

  LOOTS, MELANIE J.;KARANEWSKY, DONALD S.

  摘要：

  DOI：

文献信息

• Facile Synthesis of bis‐α‐Aminoalkylphosphinates
  作者：Marcin Drag、Katarzyna Dlugosz、Józef Oleksyszyn

  DOI：10.1080/00397910600767330

  日期：2006.9.1

  Abstract Herein we report a facile synthesis of esters of bis‐α‐aminoalkylphosphinic acids obtained by an addition of Cbz‐protected phosphinic analogues of amino acid methyl esters to an appropriate imine in refluxing benzene. Complete deprotection of the esters could be achieved in one step by the action of 30% HBr in acetic acid.

  摘要 在此，我们报告了通过在回流苯中将 Cbz 保护的氨基酸甲酯的次膦酸类似物添加到适当的亚胺中获得的双-α-氨基烷基次膦酸的酯的简便合成。通过在乙酸中的 30% HBr 的作用，可以一步实现酯的完全脱保护。
• Synthesis of α1-(Cbz-aminoalkyl)-α2-(hydroxyalkyl)phosphinic esters
  作者：Marcin Drag、Józef Oleksyszyn

  DOI：10.1016/j.tetlet.2005.03.083

  日期：2005.5

  A synthesis of alpha(1)-(Cbz-aminoalkyl)-alpha(2)-(hydroxyalkyl)phosphinic esters was achieved by the 1,2-addition of the appropriate aldehyde to Cbz-protected phosphinic analogues of amino acid esters in the presence of at least three equivalents of trimethylsilyl chloride and NEt3. The complete deprotection of the product esters could be achieved in one step using 35% HBr in acetic acid. (c) 2005 Elsevier Ltd. All rights reserved.
• Synthesis of methionine- and norleucine-derived phosphinopeptides
  作者：Radek Liboska、Jan Pícha、Ivona Hančlová、Miloš Buděšínský、Miloslav Šanda、Jiří Jiráček

  DOI：10.1016/j.tetlet.2008.07.062

  日期：2008.9

  We present herein a straightforward synthesis of N-Fmoc-protected synthons derived from a phosphinic analogue of methionine. These precursors were used Successfully for the solid-phase synthesis of methionine-mimic phosphinopeptides using BOP-catalyzed coupling without protection of the phosphoryl moiety. We also prepared a new type of pseudopeptide derived from a phosphinic analogue of norleucine with a -PO(OH)-CH(2)-COOR moiety. (C) 2008 Elsevier Ltd. All rights reserved.
• Synthesis of 1-(N-Benzyloxycarbonylamino)-5-(N-terbutyloxycarbonylamino)pentylphosphinic Acid
  作者：Alain Lecoq、Athanasis Yiotakis、Vincent Dive

  DOI：10.1080/00397919408010608

  日期：1994.11

  A procedure for the preparation of the suitable protected phosphinic analogue of lysine is described, starting from the commercially available 3-4 dihydro-2H pyran.