1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine
• 英文别名: 1-Pyridin-2-ylpyrazolo[3,4-b]pyridine
• 化学式: C₁₁H₈N₄
• 分子量: 196.211
• InChiKey: QVGIRTRQVCFUSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯吡啶 、 1H-吡唑并[3,4-B]吡啶 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 zinc diacetate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以98%的产率得到1-(pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine
  参考文献：
  名称：

  醋酸锌促进的杂芳香胺的布赫瓦尔德-哈特维格偶联

  摘要：

  锌盐已显示出促进布赫瓦尔德-哈特维希与杂芳基氯化物的氮杂吲哚和氮杂吲唑的耦合，得到相应的1-芳基1 ħ -azaindoles和1-芳基1 ħ -azaindazoles。探索了该反应的底物范围和机理方面。

  DOI：

  10.1021/acs.joc.7b01101

文献信息

• Methods and materials for identifying agents which modulate bone remodeling and agents identified thereby
  申请人：Chatterjee-Kishore Moitreyee

  公开号：US20060252045A1

  公开（公告）日：2006-11-09

  The invention discloses compositions, compounds, apparatuses and methods of using them to study bone mineralization and identify agents that regulate bone mineralization. Methods of using bone mineralization gene profiles and signatures for compound screening and research are also disclosed. Reagents for modulating bone mineralization are provided for both therapeutic and research usage.

  本发明揭示了用于研究骨矿化和鉴定调节骨矿化的药物的组合物、化合物、装置和使用方法。还揭示了使用骨矿化基因谱和签名进行化合物筛选和研究的方法。提供了用于调节骨矿化的试剂，可用于治疗和研究。
• 6H-Isoxazol[5,4-d]pyrazolo[3,4-b]pyridines, a process and intermediates for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0230622A1

  公开（公告）日：1987-08-05

  There are disclosed compounds having the formula wherein R₁ is hydrogen, loweralkyl, arylloweralkyl, aryl or heteroaryl; R₂ is hydrogen or loweralkyl; R₃ is loweralkyl, loweralkoxyloweralkyl, cycloalkyl, arylloweralkyl or heteroarylmethyl; and R₄ is hydrogen or loweralkyl; or a pharmaceutically acceptable acid addition salt thereof, which are useful for alleviating pain and lowering blood pressure, methods for synthesizing them, and pharmaceutical compositions comprising an effective amount of such a compound.

  本发明公开了具有以下式子的化合物 其中 R₁ 是氢、低级烷基、芳基低级烷基、芳基或杂芳基；R₂ 是氢或低级烷基；R₃ 是低级烷基、低级烷氧基低级烷基、环烷基、芳基低级烷基或杂芳基甲基； 和 R₄ 是氢或低级烷基；或其药学上可接受的酸加成盐，可用于减轻疼痛和降低血压，其合成方法和包含有效量此类化合物的药物组合物。
• METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY
  申请人：Wyeth

  公开号：EP1636388A2

  公开（公告）日：2006-03-22
• [EN] METHODS AND MATERIALS FOR IDENTIFYING AGENTS WHICH MODULATE BONE REMODELING AND AGENTS IDENTIFIED THEREBY<br/>[FR] PROCEDES ET MATERIAUX PERMETTANT D'IDENTIFIER DES AGENTS MODULANT LE REMODELAGE OSSEUX, ET AGENTS AINSI IDENTIFIES
  申请人：WYETH CORP

  公开号：WO2005028678A2

  公开（公告）日：2005-03-31

  The invention discloses compositions, compounds, apparatuses and methods of using them to study bone mineralization and identify agents that regulate bone mineralization. Methods of using bone mineralization gene profiles and signatures for compound screening and research are also disclosed. Reagents for modulating bone mineralization are provided for both therapeutic and research usage.
• Zinc Acetate-Promoted Buchwald–Hartwig Couplings of Heteroaromatic Amines
  作者：Rajaram Ayothiraman、Sundaramurthy Rangaswamy、Prantik Maity、Eric M. Simmons、Gregory L. Beutner、Jacob Janey、Daniel S. Treitler、Martin D. Eastgate、Rajappa Vaidyanathan

  DOI：10.1021/acs.joc.7b01101

  日期：2017.7.21

  Zinc salts have been shown to promote the Buchwald–Hartwig coupling of azaindoles and azaindazoles with heteroaryl chlorides to provide the corresponding 1-aryl-1H-azaindoles and 1-aryl-1H-azaindazoles. The substrate scope and mechanistic aspects of this reaction were explored.

  锌盐已显示出促进布赫瓦尔德-哈特维希与杂芳基氯化物的氮杂吲哚和氮杂吲唑的耦合，得到相应的1-芳基1 ħ -azaindoles和1-芳基1 ħ -azaindazoles。探索了该反应的底物范围和机理方面。