2',5'-dichloro-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',5'-dichloro-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one
• 英文别名: 3-(2,5-Dichlorophenyl)cyclohex-2-en-1-one
• 化学式: C₁₂H₁₀Cl₂O
• 分子量: 241.117
• InChiKey: UDJBHSJWXZXIFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 eosin 作用下， 以 乙腈 为溶剂， 反应 2.33h， 以79%的产率得到2',5'-dichloro-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one
  参考文献：
  名称：

  Visible Light Promoted Allylic C–H Oxidation

  摘要：

  A mild and efficient one-pot visible light-induced method has been developed for the allylic oxidation. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied C-H functionalization, owing to the utility of enones. The allylic C-H oxidation is relatively simple and predictable, even on a preparative scale, because active species generated at the allylic position are stabilized by the double bond.

  DOI：

  10.5562/cca3126

文献信息

• Palladium-Catalyzed Oxidative Heck Coupling of Cyclic Enones with Simple Arenes by CH Activation
  作者：Leung Gulice Yiu Chung、Nur Asyikin Binte Juwaini、Jayasree Seayad

  DOI：10.1002/cctc.201500079

  日期：2015.4.20

  A simple catalyst system consisting of Pd(OAc)2 and 3‐nitropyridine for the aerobic oxidative Heck coupling of cyclic enones, in particular challenging unsubstituted cyclic enones, with simple arenes by CH activation was investigated. This novel method was applied to various functionalized arenes and cyclic enones and allowed the synthesis of β‐aryl cyclic enones in modest to high yields.

  研究了由Pd（OAc）2和3-硝基吡啶组成的简单催化剂体系，用于通过CH活化将简单的芳烃与环状烯酮，特别是具有挑战性的未取代环状烯酮进行好氧氧化Heck偶联。这种新方法被应用于各种功能化的芳烃和环状烯酮，并允许以中等至高收率合成β-芳基环状烯酮。
• Visible Light Promoted Allylic C–H Oxidation
  作者：Vishal Srivastava、Pravin K. Singh、Praveen P. Singh

  DOI：10.5562/cca3126

  日期：——

  A mild and efficient one-pot visible light-induced method has been developed for the allylic oxidation. The oxidation of allylic systems has played a prominent role in this context as possibly the most widely applied C-H functionalization, owing to the utility of enones. The allylic C-H oxidation is relatively simple and predictable, even on a preparative scale, because active species generated at the allylic position are stabilized by the double bond.