Ethyl α-(p-chlorophenyl)isovalerate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl α-(p-chlorophenyl)isovalerate
• 英文别名: Ethyl 2-(4-chlorophenyl)-3-methylbutanoate
• 化学式: C₁₃H₁₇ClO₂
• mdl: MFCD16662889
• 分子量: 240.73
• InChiKey: UZUNSAOKQRFPBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴代异戊酸乙酯 、 1,4-二氯苯 以26.4%的产率得到Ethyl α-(p-chlorophenyl)isovalerate
  参考文献：
  名称：

  Process for producing .alpha.-arylalkanoic acid ester

  摘要：

  一种用于生产α-芳基烷基酸酯的方法，该酯由通式##STR1##表示，其中Ar代表可能被取代的芳基，而R^1和R^2分别表示独立的低碳基团，所述方法包括将由通式Ar-X^1（II）表示的芳基卤代烃（其中Ar如上定义，X^1代表卤素原子）和镁制备的格氏试剂与通式##STR2##表示的α-卤代烷基酸酯（其中R^1和R^2如上定义，X^2代表卤素原子）反应，其中所述格氏试剂与通式（III）的α-卤代烷基酸酯的反应在镍化合物存在下进行。

  公开号：

  US04433160A1

文献信息

• Process for producing alpha-arylalkanoic acid esters
  申请人：TAISHO PHARMACEUTICAL CO. LTD

  公开号：EP0074008A2

  公开（公告）日：1983-03-16

  A process for producing an a-arylalkanoic acid ester represented by the general formula wherein Ar represents an aryl group which may optionally be substituted, and R' and R2, independently from each other, represents a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula wherein Ar is as defined above and X1 represents a halogen atom, and magnesium, with an a-haloalkanoic acid ester of the general formula wherein R' and R2 are as defined above, and X2 represents a halogen atom, said reaction of the Grignard reagent with the a-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.

  一种生产由通式表示的a-芳基烷酸酯的工艺，通式中Ar代表可选择被取代的芳基，而R'和R2彼此独立地代表低级烷基，该工艺包括将由通式中Ar如上所定义，X1代表卤素原子的芳基卤化物和镁制备的格氏试剂与通式中R'和R2如上所定义，X2代表卤素原子的a-卤代烷酸酯反应，所述格氏试剂与通式(III)的a-卤代烷酸酯的反应在镍化合物存在下进行。
• Botteghi, Carlo; Bona, Denis Dalla; Paganelli, Stefano, Anales de Quimica, 1996, vol. 92, # 2, p. 101 - 107
  作者：Botteghi, Carlo、Bona, Denis Dalla、Paganelli, Stefano、Marchetti, Mauro、Sechi, Barbara

  DOI：——

  日期：——
• MANGANESE-CATALYSED HYDROGENATION OF ESTERS
  申请人：University Court of the University of St Andrews

  公开号：US20210053932A1

  公开（公告）日：2021-02-25

  The present invention relates to the field of catalytic hydrogenation and, more particularly, to methods of manganese-catalysed hydrogenation of esters to alcohols. Advantageously, where the esters are chiral, the hydrogenations proceed with high or complete stereochemical integrity.
• US4433160A
  申请人：——

  公开号：US4433160A

  公开（公告）日：1984-02-21
• Process for producing .alpha.-arylalkanoic acid ester
  申请人：Taisho Pharmaceutical Company, Ltd.

  公开号：US04433160A1

  公开（公告）日：1984-02-21

  A process for producing an .alpha.-arylalkanoic acid ester represented by the general formula ##STR1## wherein Ar represents an aryl group which may optionally be substituted, and R.sup.1 and R.sup.2, independently from each other, represent a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula Ar--X.sup.1 (II) wherein Ar is as defined above and X.sup.1 represents a halogen atom, and magnesium, with an .alpha.-haloalkanoic acid ester of the general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and X.sup.2 represents a halogen atom, said reaction of the Grignard reagent with the .alpha.-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.

  一种用于生产α-芳基烷基酸酯的方法，该酯由通式##STR1##表示，其中Ar代表可能被取代的芳基，而R^1和R^2分别表示独立的低碳基团，所述方法包括将由通式Ar-X^1（II）表示的芳基卤代烃（其中Ar如上定义，X^1代表卤素原子）和镁制备的格氏试剂与通式##STR2##表示的α-卤代烷基酸酯（其中R^1和R^2如上定义，X^2代表卤素原子）反应，其中所述格氏试剂与通式（III）的α-卤代烷基酸酯的反应在镍化合物存在下进行。