2-[(4-Bromoanilino)methylidene]propanedinitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-Bromoanilino)methylidene]propanedinitrile
• 化学式: C₁₀H₆BrN₃
• 分子量: 248.08
• InChiKey: FRJZUNXHVJRSLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  59.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• JAB1 inhibitory compositions for ossification and methods related thereto
  申请人：Boden Scott D.

  公开号：US11179500B2

  公开（公告）日：2021-11-23

  This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

  本公开涉及用于形成骨的化合物和组合物及其相关方法。在某些实施方案中，本公开涉及形成骨的方法，包括将包含生长因子（如 BMP）的骨移植组合物与 JAB1 阻断剂结合植入受试者需要骨生长或增强的部位。
• JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO
  申请人：Boden Scott D.

  公开号：US20130344165A1

  公开（公告）日：2013-12-26

  This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.
• JAB1 Inhibitory Compositions for Ossification and Methods Related Thereto
  申请人：Emory University

  公开号：US20220023506A1

  公开（公告）日：2022-01-27

  This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.
• [EN] JAB1 BLOCKING COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO<br/>[FR] COMPOSITIONS ANTAGONISTES DE JAB1 POUR OSSIFICATION ET PROCÉDÉS ASSOCIÉS À CELLES-CI
  申请人：UNIV EMORY

  公开号：WO2012116137A2

  公开（公告）日：2012-08-30

  This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.