N,N’-disuccinimidyl carbonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N,N’-disuccinimidyl carbonate
• 英文别名: N,N-disuccinimidyl carbamate；(2,5-dioxopyrrolidin-1-yl) N-(2,5-dioxopyrrolidin-1-yl)carbamate
• 化学式: C₉H₉N₃O₆
• 分子量: 255.187
• InChiKey: QNSSNYMNAJAJCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N,N’-disuccinimidyl carbonate 、 (2S,4S)-4-((2S,3S)-2-((2S,3S)-2-((tert-butyldimethylsilyl)oxy)-6-((4-methoxybenzyl)oxy)-3-methylhexyl)-3,5-dimethyl-4-oxo-3,4-dihydro-2H-pyran-6-yl)-2-ethylpentanoic acid 在 2,4,6-三甲基吡啶 作用下， 以 乙腈 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Sanglifehrin A 和 B 及其类似物的对映选择性合成和生物学评价

  摘要：

  Sanglifehrin A 和 B 是免疫抑制性大环天然产物，具有独特的螺环内酰胺并由其区分。在此，我们报告了 sanglifehrin A 和 B 以及类似物的对映选择性全合成和生物学评价。获得螺环内酰胺是通过关键的吡喃酮中间体的会聚组装，然后是立体控制的螺环化来实现的。22 元大环核是在 2,6-双（三氟甲基）苯硼酸 (BFBB) 存在下通过闭环复分解合成的。螺环内酰胺和大环片段通过Stille偶联结合，以提供相思蛋白A和B。另外制备在C40位置具有变化的其它相思蛋白B类似物。生物学评价表明，2-CF 3在 Jurkat 细胞中，sanglifehrin B 的类似物表现出比天然产物 sanglifehrin A 和 B 更高的抗增殖活性。两种天然产物均诱导亲环蛋白 A (CypA) 的高阶同二聚化，但只有 sanglifehrin A 促进 CypA 与肌苷-5'-单磷酸脱氢酶 2

  DOI：

  10.1002/anie.202103022

文献信息

• Detection and assay devices and methods of making and using the same
  申请人：Sentilus Holdco, LLC

  公开号：US10288607B2

  公开（公告）日：2019-05-14

  An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

  生物分子检测器或生物传感器等具有防污表面的物品包括(a) 具有表面部分的基底；(b) 表面部分上的连接层；(c) 在连接层上形成的聚合物层；(d) 与聚合物层结合的特异性结合对的第一成员（如蛋白质、肽、抗体、核酸等）。此外，还介绍了制造和使用这些物品的方法。
• EP1437344
  申请人：——

  公开号：——

  公开（公告）日：——
• DETECTION ASSAY DEVICES AND METHODS OF MAKING AND USING THE SAME
  申请人：Chilkoti Ashutosh

  公开号：US20090247424A1

  公开（公告）日：2009-10-01

  An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes:(a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
• Detection and Assay Devices and Methods of Making and Using the Same
  申请人：Sentilus, Inc.

  公开号：US20140228249A1

  公开（公告）日：2014-08-14

  An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.
• DETECTION AND ASSAY DEVICES AND METHODS OF MAKING AND USING THE SAME
  申请人：Sentilus Holdco LLC

  公开号：US20190285623A1

  公开（公告）日：2019-09-19

  An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.