royleanonic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: royleanonic acid
• 英文别名: royleanoic acid
• 化学式: C₂₀H₂₆O₅
• 分子量: 346.423
• InChiKey: TWZMQZBMHUHORI-FKIZINRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  91.67
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 royleanonic acid 在 吡啶 作用下， 反应 4.0h， 以1.2 mg的产率得到
  参考文献：
  名称：

  Antioxidant Mechanism of Carnosic Acid:  Structural Identification of Two Oxidation Products

  摘要：

  To determine the antioxidant mechanism of food phenolics against the oxidation of food components, the reaction of carnosic acid, an antioxidative constituent of the popular herbs sage and rosemary, was investigated in the presence of ethyl linoleate and the radical oxidation initiator 2,2'-azobis-(2,4-dimethylvaleronitrile). During this process, carnosic acid was oxidized to an o-quinone and a hydroxy p-quinone, the chemical structures of which were confirmed by physical and chemical techniques, From a quantitative time course analysis of the production of these quinones, an antioxidant mechanism of carnosic acid is proposed, consisting of the oxidative coupling reaction with the peroxyl radical at the 12- or 14-position of carnosic acid and subsequent degradation reactions.

  DOI：

  10.1021/jf010693i
• 作为产物：
  描述：

  鼠尾草酸 在 air 、 三氯化铁 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以8 mg的产率得到鼠尾草酸醌
  参考文献：
  名称：

  Antioxidant Mechanism of Carnosic Acid:  Structural Identification of Two Oxidation Products

  摘要：

  To determine the antioxidant mechanism of food phenolics against the oxidation of food components, the reaction of carnosic acid, an antioxidative constituent of the popular herbs sage and rosemary, was investigated in the presence of ethyl linoleate and the radical oxidation initiator 2,2'-azobis-(2,4-dimethylvaleronitrile). During this process, carnosic acid was oxidized to an o-quinone and a hydroxy p-quinone, the chemical structures of which were confirmed by physical and chemical techniques, From a quantitative time course analysis of the production of these quinones, an antioxidant mechanism of carnosic acid is proposed, consisting of the oxidative coupling reaction with the peroxyl radical at the 12- or 14-position of carnosic acid and subsequent degradation reactions.

  DOI：

  10.1021/jf010693i

文献信息

• USE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS AND/OR JOINT DISORDERS
  申请人：Raederstorff Daniel

  公开号：US20100056615A1

  公开（公告）日：2010-03-04

  The present invention refers to the use of at least one tricyclic diterpenes for the manufacture of a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders.