3,4-bi(4-carboxyphenyl)benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-bi(4-carboxyphenyl)benzoic acid
• 英文别名: 3,4-Bis(4-carboxyphenyl)benzoic acid；3,4-bis(4-carboxyphenyl)benzoic acid
• 化学式: C₂₁H₁₄O₆
• 分子量: 362.339
• InChiKey: CPZAKZOVPBOVGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3,4-bi(4-carboxyphenyl)benzoic acid 在 strontium(II) nitrate tetrahydrate 、 水 作用下， 反应 72.0h， 以58%的产率得到
  参考文献：
  名称：

  Crystal Structure and Evaluation of the Anti-Gastric Cancer Activity of a New Sr(II)-Based Coordination Polymer

  摘要：

  In this study, a new Sr(II)-based coordination polymer containing Sr(II)-carboxyl chains with the formula [Sr-3(L)(2)(H2O)(2)](H2O)(3)is successfully prepared with the use of a non-planar tripodal ligand 3,4-bixx(4-carboxyphenyl)-benzoic acid (H3L) under the hydrothermal conditions. A single crystal X-ray diffraction study reveals that complex1has a three-dimensional framework with a 3-nodal (4,6,8)-connected topological net. Furthermore, an ultrasonic treatment method is used to produce the crystalline samples of1in the nanoscale (nano1).The CKK-8 assay is performed to detect the cell proliferation of MGC-803 gastric cancer cells under the treatment with nano1.Moreover, the cancer cell apoptosis is determined by a flow cytometer and the Western blot after treating with nano1.

  DOI：

  10.1134/s0022476620040095

文献信息

• Ionic liquid templated novel porous anionic cobalt(II) coordination framework based on rod-shaped metal-carboxylate chains
  作者：Jian-Hua Qin、Ya-Dan Huang、Fei-Fei Li

  DOI：10.1080/24701556.2019.1567545

  日期：2019.1.2

  the ultimate structure. Complex 1 possesses 1D channels (11.4 × 13.6 Å) constructed by 1D cobalt(II)-carboxylate secondary building unit (SBU) and H3L ligands. The study suggests that [BMI]Br, the kind of molecular solvents as well as the anion of the cobalt(II) salts all play key roles in the formation of the title anionic framework.

  基于棒状金属羧酸盐链[BMI] [Co 3（L）2（HCOO）（H 2 O）2 ]（1）（H 3 L = 3，在溶剂热和电热合成的结合下，制备了4-双（4-羧苯基）-苯甲酸，[BMI] Br = 1-丁基-3-甲基咪唑鎓溴化物。[BMI] Br离子液体起结构指导作用，[BMI] +阳离子被封闭在最终结构中。配合物1具有1D通道（11.4×13.6Å），该通道由1D钴（II）-羧酸盐二级建筑单元（SBU）和H 3构成L配体。研究表明，[BMI] Br，分子溶剂的种类以及钴（II）盐的阴离子均在标题阴离子骨架的形成中起关键作用。
• A Novel (3,4,9)-Connected 3D Metal–Organic Framework Based on the Non-Planar Tricarboxyl Tecton and Zn5O4-Cluster SBU
  作者：Zhuo-Wei Wang、Hui Zhao、Min Chen、Min Hu

  DOI：10.1071/ch14392

  日期：——

  Combination of a non-planar tripodal ligand 3,4-bi(4-carboxyphenyl)-benzoic acid (H3L) and Zn5O4-cluster secondary building units affords a highly connected three-dimensional metal–organic framework, [Zn5(μ3-OH)3(μ2-OH)L2(H2O)2](H2O)2}n (1), which exhibits an unusual (3,4,9)-connected (42.5)(3.43.52)(32.45.511.613.73.82) topological net. The thermal stability and solid luminescence of the crystalline material have also been investigated.

  将非平面三元配体 3,4-双（4-羧基苯基）-苯甲酸（H3L）和 Zn5O4 簇二级构建单元结合在一起，就产生了一个高度连接的三维金属有机框架 [Zn5(μ3-OH)3(μ2-OH)L2(H2O)2](H2O)2}n (1)，它呈现出不寻常的（3,4,9）连接（42.5)(3.43.52)(32.45.511.613.73.82) 拓扑网。此外，还对晶体材料的热稳定性和固体发光进行了研究。
• Crystal Structure and Evaluation of the Anti-Gastric Cancer Activity of a New Sr(II)-Based Coordination Polymer
  作者：L. Han、X. Li、B. Yan、X. Han、C. Wang、W. Yang、X. Liu

  DOI：10.1134/s0022476620040095

  日期：2020.4

  In this study, a new Sr(II)-based coordination polymer containing Sr(II)-carboxyl chains with the formula [Sr-3(L)(2)(H2O)(2)](H2O)(3)is successfully prepared with the use of a non-planar tripodal ligand 3,4-bixx(4-carboxyphenyl)-benzoic acid (H3L) under the hydrothermal conditions. A single crystal X-ray diffraction study reveals that complex1has a three-dimensional framework with a 3-nodal (4,6,8)-connected topological net. Furthermore, an ultrasonic treatment method is used to produce the crystalline samples of1in the nanoscale (nano1).The CKK-8 assay is performed to detect the cell proliferation of MGC-803 gastric cancer cells under the treatment with nano1.Moreover, the cancer cell apoptosis is determined by a flow cytometer and the Western blot after treating with nano1.