乙氧基-甲基-(4-甲硫基苯氧基)-巯基膦烷 | 2703-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 乙氧基-甲基-(4-甲硫基苯氧基)-巯基膦烷
• 英文名称: Methyl-phosphonothioic acid O-ethyl ester O-(4-methylsulfanyl-phenyl) ester
• 英文别名: Phosphonothioic acid, methyl-, O-ethyl O-(4-(methylthio)phenyl) ester；ethoxy-methyl-(4-methylsulfanylphenoxy)-sulfanylidene-λ5-phosphane
• CAS: 2703-13-1
• 化学式: C₁₀H₁₅O₂PS₂
• 分子量: 262.334
• InChiKey: LUCDVNXIIQYRLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  334.2±44.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)
• 物理描述：
  Phosphonothioic acid, methyl-, o-ethyl o-(4-(methylthio)phenyl) ester is a liquid. (EPA, 1998)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75.8
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 副作用

其他毒物 - 有机磷

Other Poison - Organophosphate

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

一个昏迷的病人，全身出汗，瞳孔缩小，衣物或呼吸中有杀虫剂的气味，并且肌肉出现颤动，这是有机磷中毒的典型表现。... 管理的具体步骤包括以下内容。1. 去污。... 2. 气道。如有必要，建立气道。... 3. 呼吸状态。事实上，这些病人由于多种原因经常出现呼吸窘迫。... 4. 心脏监测。... 5. 胆碱酯酶水平。... 6. 普瑞洛昔姆。普瑞洛昔姆是有机磷中毒的首选治疗方法，应几乎用于所有临床上有显著有机磷中毒的病人，特别是那些肌肉颤动和虚弱的病人。... 7. 阿托品。阿托品是有机磷中毒的生理性拮抗剂。当怀疑有机磷中毒时，应基于临床情况给予试验剂量的阿托品。/有机磷中毒/

A comatose patient who is diaphoretic, has pinpoint pupils and the odor of an insecticide on clothing or breath, and is noted to have muscle fasciculations represents the classic presentation of organophosphate poisoning. ... Specific steps in management include the following. 1. Decontamination. ... 2 Airway. Establish an airway if necessary. ... 3. Respiratory Status. Respiratory distress, in fact, is commonly found in these patients from multiple causes. ... 4. Cardiac Monitoring. ... 5. Cholinesterase Level. ... 6. Pralidoxime. Pralidoxime is the treatment of choice for organophosphate poisoning and should be used for nearly all patients with clinically significant orgnophosphate poisoning,particularly whose patients with muscular fasciculations and weakness. ... 7. Atropine. Atropine is the physiologic antidote for organophosphate poisoning. A trial dose of atropine should be instituted on clinical ground when one suspects organophosphate intoxication. /Organophosphate poisoning/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

有机磷化合物可能会产生皮肤刺激，但大多数是轻微的致敏剂。/有机磷酸盐化合物/

Organophosphorus cmpd can produce dermal irritation but most are weak sensitizers. /Organophosphate cmpd/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

大多数有机磷化合物可以通过皮肤、结膜、胃肠系统和肺部被吸收。/有机磷化合物/

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 海关编码：
  2930909027
• 包装等级：
  II
• 危险类别：
  6.1(a)

文献信息

• Methods and compositions for increasing the efficacy of biologically-active ingredients
  申请人：Windsor Brian J.

  公开号：US20060276339A1

  公开（公告）日：2006-12-07

  The invention provides methods and compositions for modulating the sensitivity of cells to cytotoxic compounds and other active agents. In accordance with the invention, compositions are provided comprising combinations of ectophosphatase inhibitors and active agents. Active agents include antibiotics, fungicides, herbicides, insecticides, chemotherapeutic agents, and plant growth regulators. By increasing the efficacy of active agents, the invention allows use of compositions with lowered concentrations of active ingredients.