2-amino-4-chloro-6-(2,5-dichlorophenyl)-1,3,5-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-4-chloro-6-(2,5-dichlorophenyl)-1,3,5-triazine
• 英文别名: 2-Amino-4-chloro-6-(2,5-dichlorophenyl)-s-triazine；4-chloro-6-(2,5-dichlorophenyl)-1,3,5-triazin-2-amine
• 化学式: C₉H₅Cl₃N₄
• 分子量: 275.524
• InChiKey: HGUHPEDYUHSPEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-amino-4-chloro-6-(2,5-dichlorophenyl)-1,3,5-triazine 生成 N-[4-amino-6-(2,5-dichlorophenyl)-1,3,5-triazin-2-yl]pyridine-3-carboxamide
  参考文献：
  名称：

  MATSUMURA, SHINGO;ENOMOTO, HIROSHI;AOYAGI, YOSHIAKI;SHIBATA, YOSHIHISA

  摘要：

  DOI：

文献信息

• Triazine derivative and medicine
  申请人：Nippon Shinyaku Co. Ltd.

  公开号：US05962453A1

  公开（公告）日：1999-10-05

  The invention relates to a medicinal composition comprising a triazine derivative of the following general formula \x9bI! ##STR1## or a solvate thereof, or a salt thereof, as an active ingredient. In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, unsubstituted or substituted alkyl aralkyl, or alkenyl, or jointly represent cyclic amino (NR.sup.1 R.sup.2) in combination with the adjacent nitrogen atom. The cyclic amino may contain nitrogen, oxygen, or sulfur as a ring member in addition to the adjacent nitrogen and may be further substituted. Excluded is the case in which NR.sup.1 R.sup.2 is NH.sub.2. The compound of the invention is useful as a therapeutic drug for hepatitis.

  该发明涉及一种药物组合物，其包括以下一般式的三嗪衍生物\x9bI! ##STR1## 或其溶剂化物，或其盐，作为活性成分。在上述式中，R.sup.1和R.sup.2可以相同也可以不同，每个代表氢，未取代或取代的烷基芳基，或烯基，或者共同代表与相邻氮原子结合的环状氨基（NR.sup.1 R.sup.2）。该环状氨基除了相邻氮原子外，还可以包含氮、氧或硫作为环成员，并且可能进一步取代。不包括NR.sup.1 R.sup.2为NH.sub.2的情况。该发明的化合物可用作治疗肝炎的治疗药物。
• Remedy for pancreatitis
  申请人：Nippon Shinyaku Company, Limited

  公开号：US05885993A1

  公开（公告）日：1999-03-23

  The invention relates to a therapeutic drug for pancreatitis which comprises a compound of the following general formula \x9bI! or a salt thereof, or a solvate thereof. ##STR1## In the above formula, R.sup.1 and R.sup.2 may be the same or different and each represents hydrogen, alkyl which may be substituted, aralkyl, arylalkenyl, or aryl, or R.sup.1 and R.sup.2 taken together with the adjacent N atom, i.e. in the form of NR.sup.1 R.sup.2, represent a 4- through 8-membered cyclic amino group, which cyclic amino group may contain nitrogen, oxygen, or sulfur as a ring member in addition to the above-mentioned N atom and may be further substituted.

  该发明涉及一种治疗胰腺炎的药物，包括以下通用公式\x9bI!的化合物或其盐，或其溶剂化合物。在上述公式中，R.sup.1和R.sup.2可以相同也可以不同，每个代表氢、可以被取代的烷基、芳基烷基、芳基烯基或芳基，或者R.sup.1和R.sup.2与相邻的N原子一起，即以NR.sup.1 R.sup.2的形式，代表一个4至8元环氨基团，该环氨基团除了上述N原子外，还可以包含氮、氧或硫作为环成员，并且可以进一步取代。
• Neovascularization inhibitor
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：US05962454A1

  公开（公告）日：1999-10-05

  The invention relates to a neovascularization inhibitor composition comprising a compound of the following general formula \x9bI! or a salt thereof, or a solvate thereof, as an active ingredient, ##STR1## wherein R.sup.1 represents hydrogen, optionally substituted alkyl, aralkyl, arylalkenyl, or aryl; R.sup.2 represents optionally substituted alkyl, aralkyl, arylalkenyl, or aryl; or R.sup.1 and R.sup.2 conjoinedly and taken together with the adjacent N atom, i.e. in the form of NR.sup.1 R.sup.2, represent a 4- through 8-membered cyclic amino group optionally containing nitrogen, oxygen, or sulfur as a ring member in addition to said N atom and optionally being further substituted.

  该发明涉及一种新生血管抑制剂组合物，其包括以下通用公式\x9bI!的化合物或其盐或溶剂化合物作为活性成分，其中R.sup.1代表氢、可选地取代的烷基、芳基烷基、芳基烯基或芳基；R.sup.2代表可选地取代的烷基、芳基烷基、芳基烯基或芳基；或者R.sup.1和R.sup.2共同和与相邻的N原子一起，即以NR.sup.1 R.sup.2的形式，代表一个4-至8-成员环氨基组，该环氨基组可选地含有氮、氧或硫作为环原子，除了所述的N原子外，还可选地进一步取代。
• [EN] DIAMINOTRIAZINE COMPOUND<br/>[FR] COMPOSÉ DE DIAMINOTRIAZINE
  申请人：BASF SE

  公开号：WO2015155129A1

  公开（公告）日：2015-10-15

  The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation.

  本发明涉及公式（I）的二氨基三嗪化合物及其作为除草剂的用途。本发明还涉及用于作物保护的农业化学组合物以及一种控制不良植被的方法。
• Nicotinic acid derivatives
  申请人：Nippon Shinyaku Co. Ltd.

  公开号：US04415570A1

  公开（公告）日：1983-11-15

  Compounds useful in the treatment of rheumatism or allergic nephritis which have the formula ##STR1## wherein X is halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, nitro or amino; Y is hydrogen, halogen, hydroxy, lower alkyl, lower alkenyl, lower alkoxy, nitro or amino; and Z is mono-(lower alkyl)amino, di-(lower alkyl)amino, piperidino, piperazino, pyrrolidino, or morpholino.

  该化合物的分子式为##STR1##，其中X为卤素、羟基、较低的烷基、较低的烯基、较低的烷氧基、硝基或氨基；Y为氢、卤素、羟基、较低的烷基、较低的烯基、较低的烷氧基、硝基或氨基；Z为单-(较低烷基)氨基、双-(较低烷基)氨基、哌啶基、哌嗪基、吡咯烷基或吗啡环基，可用于治疗风湿病或过敏性肾炎。